Discovering a New Okadaic Acid Derivative, a Potent HIV Latency Reversing Agent from <i>Prorocentrum lima</i> PL11: Isolation, Structural Modification, and Mechanistic Study

Discovering a New Okadaic Acid Derivative, a Potent HIV Latency Reversing Agent from <i>Prorocentrum lima</i> PL11: Isolation, Structural Modification, and Mechanistic Study

Marine toxins (MTs) are a group of structurally complex natural products with unique toxicological and pharmacological activities. In the present study, two common shellfish toxins, okadaic acid (OA) (<b>1</b>) and OA methyl ester (<b>2</b>), were isolated from the cultured m...

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Detalhes bibliográficos
Main Authors: Dong Huang, Lian-Shuai Ding, Fang-Yu Yuan, Shu-Qi Wu, Han-Zhuang Weng, Xiao-Qing Tian, Gui-Hua Tang, Cheng-Qi Fan, Xiang Gao, Sheng Yin
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2023-02-01
Colecção:Marine Drugs
Assuntos:
marine toxins
okadaic acid
<i>Prorocentrum lima</i> PL11
structural modification
HIV latency reversal activity
Acesso em linha:https://www.mdpi.com/1660-3397/21/3/158

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