Multivariable analysis to determine risk factors associated with abortion in mares
Risk factors associated with equine reproductive efficiency have been identified along with those associated specifically with early pregnancy loss (EPL). In contrast, no studies have reported risk factors associated with abortion (loss between days 70 and 300 post-cover). Given the causes of aborti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-12-01
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| Series: | Reproduction and Fertility |
| Subjects: | |
| Online Access: | https://raf.bioscientifica.com/view/journals/raf/3/4/RAF-22-0087.xml |
| _version_ | 1811292784243507200 |
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| author | J M Roach J C Arango-Sabogal K C Smith A K Foote K L Verheyen A M de Mestre |
| author_facet | J M Roach J C Arango-Sabogal K C Smith A K Foote K L Verheyen A M de Mestre |
| author_sort | J M Roach |
| collection | DOAJ |
| description | Risk factors associated with equine reproductive efficiency have been identified along with those associated specifically with early pregnancy loss (EPL). In contrast, no studies have reported risk factors associated with abortion (loss between days 70 and 300 post-cover). Given the causes of abortion differ from those of EPL, likely too will the risk factors. A retrospective cohort study was carried out to identify risk factors associated with abortion in UK- and Irish-based Thoroughbreds, collecting data on 20 exposure variables over a 5-year period. A generalized linear mixed model was utilized to evaluate the associations between exposure variables and abortion, with clustering of observations accounted for at the mare and farm level. Variables with a likelihood ratio test (LRT) P value < 0.2 were entered into the model in a forward stepwise approach. Pregnancy outcome was available on 4439 pregnancies from 2510 mares. Having had two or more prior abortions (odds ratio (OR): 7.91, 95% CI: 2.86, 21.88), conceiving on the second or subsequent covered estrous cycle (OR: 1.84, 95% CI: 1.22, 2.78) and conceiving multiple conceptuses (OR: 1.68, 95% CI: 1.02, 2.76) were associated with an increased risk of abortion compared to null parous, first estrous cycle covers and singleton conceptions, respectively. Increasing paternal age (OR: 0.95, 95% CI: 0.90, 0.99) was associated with a decreasing risk of abortion. Mare and farm variance were not significant in the final model, LRT P = 0.43. These findings provide evidence-based data to inform Thoroughbred breeding management practices to help mitigate abortion risk. |
| first_indexed | 2024-04-13T04:50:39Z |
| format | Article |
| id | doaj.art-6b513b11b48746afbb2259eb02e781b2 |
| institution | Directory Open Access Journal |
| issn | 2633-8386 |
| language | English |
| last_indexed | 2024-04-13T04:50:39Z |
| publishDate | 2022-12-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Reproduction and Fertility |
| spelling | doaj.art-6b513b11b48746afbb2259eb02e781b22022-12-22T03:01:40ZengBioscientificaReproduction and Fertility2633-83862022-12-0134301312https://doi.org/10.1530/RAF-22-0087Multivariable analysis to determine risk factors associated with abortion in maresJ M Roach0J C Arango-Sabogal1K C Smith2A K Foote3K L Verheyen4A M de Mestre5Comparative Biomedical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UKPathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UKPathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UKRossdales Laboratories, Newmarket, UKPathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UKComparative Biomedical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UKRisk factors associated with equine reproductive efficiency have been identified along with those associated specifically with early pregnancy loss (EPL). In contrast, no studies have reported risk factors associated with abortion (loss between days 70 and 300 post-cover). Given the causes of abortion differ from those of EPL, likely too will the risk factors. A retrospective cohort study was carried out to identify risk factors associated with abortion in UK- and Irish-based Thoroughbreds, collecting data on 20 exposure variables over a 5-year period. A generalized linear mixed model was utilized to evaluate the associations between exposure variables and abortion, with clustering of observations accounted for at the mare and farm level. Variables with a likelihood ratio test (LRT) P value < 0.2 were entered into the model in a forward stepwise approach. Pregnancy outcome was available on 4439 pregnancies from 2510 mares. Having had two or more prior abortions (odds ratio (OR): 7.91, 95% CI: 2.86, 21.88), conceiving on the second or subsequent covered estrous cycle (OR: 1.84, 95% CI: 1.22, 2.78) and conceiving multiple conceptuses (OR: 1.68, 95% CI: 1.02, 2.76) were associated with an increased risk of abortion compared to null parous, first estrous cycle covers and singleton conceptions, respectively. Increasing paternal age (OR: 0.95, 95% CI: 0.90, 0.99) was associated with a decreasing risk of abortion. Mare and farm variance were not significant in the final model, LRT P = 0.43. These findings provide evidence-based data to inform Thoroughbred breeding management practices to help mitigate abortion risk.https://raf.bioscientifica.com/view/journals/raf/3/4/RAF-22-0087.xmlmareabortionpregnancyhorserisk factor |
| spellingShingle | J M Roach J C Arango-Sabogal K C Smith A K Foote K L Verheyen A M de Mestre Multivariable analysis to determine risk factors associated with abortion in mares Reproduction and Fertility mare abortion pregnancy horse risk factor |
| title | Multivariable analysis to determine risk factors associated with abortion in mares |
| title_full | Multivariable analysis to determine risk factors associated with abortion in mares |
| title_fullStr | Multivariable analysis to determine risk factors associated with abortion in mares |
| title_full_unstemmed | Multivariable analysis to determine risk factors associated with abortion in mares |
| title_short | Multivariable analysis to determine risk factors associated with abortion in mares |
| title_sort | multivariable analysis to determine risk factors associated with abortion in mares |
| topic | mare abortion pregnancy horse risk factor |
| url | https://raf.bioscientifica.com/view/journals/raf/3/4/RAF-22-0087.xml |
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