Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
Cholesterol plays an essential role in maintaining the rigidity of cell membranes and signal transduction. Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the dist...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/9/609 |
| _version_ | 1797580671949996032 |
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| author | Zahraa Qusairy Anne Gangloff Shuk On Annie Leung |
| author_facet | Zahraa Qusairy Anne Gangloff Shuk On Annie Leung |
| author_sort | Zahraa Qusairy |
| collection | DOAJ |
| description | Cholesterol plays an essential role in maintaining the rigidity of cell membranes and signal transduction. Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the distinct role of cholesterol in ovarian cancer cell proliferation, metastasis and chemoresistance. In this review, we summarize the current findings that suggest the contribution of cholesterol homeostasis dysregulation to ovarian cancer progression and resistance to anti-cancer agents. We also discuss the therapeutic implications of cholesterol-lowering drugs in ovarian cancer. |
| first_indexed | 2024-03-10T22:53:15Z |
| format | Article |
| id | doaj.art-6b519b037b514ed797ed937386d04022 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T22:53:15Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-6b519b037b514ed797ed937386d040222023-11-19T10:11:12ZengMDPI AGCurrent Oncology1198-00521718-77292023-09-013098386840010.3390/curroncol30090609Dysregulation of Cholesterol Homeostasis in Ovarian CancerZahraa Qusairy0Anne Gangloff1Shuk On Annie Leung2Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, CanadaCHU de Québec-Université Laval Research Center, Québec City, QC G1V 4G2, CanadaCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, CanadaCholesterol plays an essential role in maintaining the rigidity of cell membranes and signal transduction. Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the distinct role of cholesterol in ovarian cancer cell proliferation, metastasis and chemoresistance. In this review, we summarize the current findings that suggest the contribution of cholesterol homeostasis dysregulation to ovarian cancer progression and resistance to anti-cancer agents. We also discuss the therapeutic implications of cholesterol-lowering drugs in ovarian cancer.https://www.mdpi.com/1718-7729/30/9/609cholesterolovarian cancercell proliferationchemoresistancemetastases |
| spellingShingle | Zahraa Qusairy Anne Gangloff Shuk On Annie Leung Dysregulation of Cholesterol Homeostasis in Ovarian Cancer Current Oncology cholesterol ovarian cancer cell proliferation chemoresistance metastases |
| title | Dysregulation of Cholesterol Homeostasis in Ovarian Cancer |
| title_full | Dysregulation of Cholesterol Homeostasis in Ovarian Cancer |
| title_fullStr | Dysregulation of Cholesterol Homeostasis in Ovarian Cancer |
| title_full_unstemmed | Dysregulation of Cholesterol Homeostasis in Ovarian Cancer |
| title_short | Dysregulation of Cholesterol Homeostasis in Ovarian Cancer |
| title_sort | dysregulation of cholesterol homeostasis in ovarian cancer |
| topic | cholesterol ovarian cancer cell proliferation chemoresistance metastases |
| url | https://www.mdpi.com/1718-7729/30/9/609 |
| work_keys_str_mv | AT zahraaqusairy dysregulationofcholesterolhomeostasisinovariancancer AT annegangloff dysregulationofcholesterolhomeostasisinovariancancer AT shukonannieleung dysregulationofcholesterolhomeostasisinovariancancer |