Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report
Abstract Background Bladder leiomyosarcoma is the most frequent mesenchymal neoplasm of the bladder. However, the rarity of the disease and some morphological aspects could give serious problems to differential diagnosis. Case presentation A 86-year-old male patient was referred to our institution t...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-5981-x |
| _version_ | 1828864161717682176 |
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| author | Vincenzo Fiorentino Francesco Pierconti Niccolò Lenci Martina Calicchia Giuseppe Palermo Pierfrancesco Bassi Luigi Maria Larocca Maurizio Martini |
| author_facet | Vincenzo Fiorentino Francesco Pierconti Niccolò Lenci Martina Calicchia Giuseppe Palermo Pierfrancesco Bassi Luigi Maria Larocca Maurizio Martini |
| author_sort | Vincenzo Fiorentino |
| collection | DOAJ |
| description | Abstract Background Bladder leiomyosarcoma is the most frequent mesenchymal neoplasm of the bladder. However, the rarity of the disease and some morphological aspects could give serious problems to differential diagnosis. Case presentation A 86-year-old male patient was referred to our institution to undergo endoscopic low-urinary-tract re-evaluation 2 months after the detection of a “low-grade urothelial neoplasia” in urinary cytology. A TURBT (transurethral resection of bladder tumor) was performed and revealed a tumor extending for 3.5 cm with thin stalk peduncle on the left lateral wall of the bladder, cephalad and lateral to the left ureteral orifice. The exophytic part of the tumor was resected with the underlying bladder wall. Histologically, the tumor showed a quite complex pattern, composed of spindle cells, with often invasion to the surrounding bladder muscular wall, and the presence of numerous multinucleated, osteoclast-like giant cells, scattered throughout the neoplasia. Conclusions Here we report a unique case of urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells (OGCs). These cells, confounding the morphological aspect, indeed showed an immunohistochemical phenotype of non-neoplastic origin (most likely a histiocyte/macrophage differentiation). We feel that the presence of the OGCs within this tumor is reactive. Nevertheless, more research is necessary to understand the role of OGCs in urinary bladder tumors and leiomyosarcoma, in paticular. |
| first_indexed | 2024-12-13T04:00:54Z |
| format | Article |
| id | doaj.art-6b55f49bbd3648cf8a493f3ee7778903 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-13T04:00:54Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-6b55f49bbd3648cf8a493f3ee77789032022-12-22T00:00:29ZengBMCBMC Cancer1471-24072019-08-011911610.1186/s12885-019-5981-xUrinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case reportVincenzo Fiorentino0Francesco Pierconti1Niccolò Lenci2Martina Calicchia3Giuseppe Palermo4Pierfrancesco Bassi5Luigi Maria Larocca6Maurizio Martini7Servizio di Istopatologia e Citodiagnosi, Fondazione Policlinico Universitario A. Gemelli IRCCSServizio di Istopatologia e Citodiagnosi, Fondazione Policlinico Universitario A. Gemelli IRCCSClinica Urologica, Fondazione Policlinico Universitario A. Gemelli IRCCSServizio di Istopatologia e Citodiagnosi, Fondazione Policlinico Universitario A. Gemelli IRCCSClinica Urologica, Fondazione Policlinico Universitario A. Gemelli IRCCSInstitute of Urology, Università Cattolica del Sacro CuoreServizio di Istopatologia e Citodiagnosi, Fondazione Policlinico Universitario A. Gemelli IRCCSServizio di Istopatologia e Citodiagnosi, Fondazione Policlinico Universitario A. Gemelli IRCCSAbstract Background Bladder leiomyosarcoma is the most frequent mesenchymal neoplasm of the bladder. However, the rarity of the disease and some morphological aspects could give serious problems to differential diagnosis. Case presentation A 86-year-old male patient was referred to our institution to undergo endoscopic low-urinary-tract re-evaluation 2 months after the detection of a “low-grade urothelial neoplasia” in urinary cytology. A TURBT (transurethral resection of bladder tumor) was performed and revealed a tumor extending for 3.5 cm with thin stalk peduncle on the left lateral wall of the bladder, cephalad and lateral to the left ureteral orifice. The exophytic part of the tumor was resected with the underlying bladder wall. Histologically, the tumor showed a quite complex pattern, composed of spindle cells, with often invasion to the surrounding bladder muscular wall, and the presence of numerous multinucleated, osteoclast-like giant cells, scattered throughout the neoplasia. Conclusions Here we report a unique case of urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells (OGCs). These cells, confounding the morphological aspect, indeed showed an immunohistochemical phenotype of non-neoplastic origin (most likely a histiocyte/macrophage differentiation). We feel that the presence of the OGCs within this tumor is reactive. Nevertheless, more research is necessary to understand the role of OGCs in urinary bladder tumors and leiomyosarcoma, in paticular.http://link.springer.com/article/10.1186/s12885-019-5981-xLeiomyosarcomaBladderOsteoclast-like multinucleated giant cells |
| spellingShingle | Vincenzo Fiorentino Francesco Pierconti Niccolò Lenci Martina Calicchia Giuseppe Palermo Pierfrancesco Bassi Luigi Maria Larocca Maurizio Martini Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report BMC Cancer Leiomyosarcoma Bladder Osteoclast-like multinucleated giant cells |
| title | Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report |
| title_full | Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report |
| title_fullStr | Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report |
| title_full_unstemmed | Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report |
| title_short | Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report |
| title_sort | urinary bladder leiomyosarcoma with osteoclast like multinucleated giant cells a case report |
| topic | Leiomyosarcoma Bladder Osteoclast-like multinucleated giant cells |
| url | http://link.springer.com/article/10.1186/s12885-019-5981-x |
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