Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-regulatory elements during lineage commitment is cru...

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Bibliographic Details
Main Authors: Paula Freire-Pritchett, Stefan Schoenfelder, Csilla Várnai, Steven W Wingett, Jonathan Cairns, Amanda J Collier, Raquel García-Vílchez, Mayra Furlan-Magaril, Cameron S Osborne, Peter Fraser, Peter J Rugg-Gunn, Mikhail Spivakov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
gene regulation
cis-regulatory units
human embryonic stem cells
lineage committment
nuclear architecture
promoter capture Hi-C
Online Access:https://elifesciences.org/articles/21926

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