Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

Abstract Background Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death. Methods We performed lipidomics using thr...

Full description

Bibliographic Details
Main Authors: Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L. Eizirik, Bobbie-Jo M. Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O. Metz, Raghavendra G. Mirmira, Lori Sussel, Charles Ansong, Ernesto S. Nakayasu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell Communication and Signaling
Online Access:https://doi.org/10.1186/s12964-023-01437-1

Similar Items

Similar Items