Population Pharmacokinetics of <i>Cis</i>-, <i>Trans</i>-, and Total Cefprozil in Healthy Male Koreans
Cefprozil, one of cephalosporin antibiotics, has been used extensively in clinics. However, pharmacokinetic (PK) information on cefprozil is still very limited. There have been no reports of population pharmacokinetics (PPKs). A PPK model for cefprozil will be a great advantage for clinical use. Thu...
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| Format: | Article |
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MDPI AG
2019-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/10/531 |
| _version_ | 1811183928210358272 |
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| author | Ji-Hun Jang Seung-Hyun Jeong Hea-Young Cho Yong-Bok Lee |
| author_facet | Ji-Hun Jang Seung-Hyun Jeong Hea-Young Cho Yong-Bok Lee |
| author_sort | Ji-Hun Jang |
| collection | DOAJ |
| description | Cefprozil, one of cephalosporin antibiotics, has been used extensively in clinics. However, pharmacokinetic (PK) information on cefprozil is still very limited. There have been no reports of population pharmacokinetics (PPKs). A PPK model for cefprozil will be a great advantage for clinical use. Thus, the aim of this study was to develop a PPK model for cefprozil for healthy male Koreans. Clinical PK and demographic data of healthy Korean males receiving cefprozil at a dose of 1000 mg were analyzed using Phoenix<sup>®</sup> NLME™. A one-compartment model with first-order absorption with lag-time was constructed as a base model. The model was extended to include covariates that influenced between-subject variability. Creatinine clearance significantly influenced systemic clearance of cefprozil. The final PPK model for <i>cis</i>-, <i>trans</i>-, and total cefprozil was established and validated. PPK parameter values of <i>cis</i>- and total cefprozil were similar to each other, but different from those of <i>trans</i>-isomer. Herein, we describe the establishment of accurate PPK models of <i>cis</i>-, <i>trans</i>-, and total cefprozil for healthy male Koreans for the first time. It may be useful as a dosing algorithm for the general population. These results might also contribute to the development of stereoisomeric cefprozil. |
| first_indexed | 2024-04-11T13:05:03Z |
| format | Article |
| id | doaj.art-6b57e3685f1543619b7f82bea92a19ab |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T13:05:03Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-6b57e3685f1543619b7f82bea92a19ab2022-12-22T04:22:48ZengMDPI AGPharmaceutics1999-49232019-10-01111053110.3390/pharmaceutics11100531pharmaceutics11100531Population Pharmacokinetics of <i>Cis</i>-, <i>Trans</i>-, and Total Cefprozil in Healthy Male KoreansJi-Hun Jang0Seung-Hyun Jeong1Hea-Young Cho2Yong-Bok Lee3College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-Gu, Gwangju 61186, KoreaCollege of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-Gu, Gwangju 61186, KoreaCollege of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-Do 13488, KoreaCollege of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-Gu, Gwangju 61186, KoreaCefprozil, one of cephalosporin antibiotics, has been used extensively in clinics. However, pharmacokinetic (PK) information on cefprozil is still very limited. There have been no reports of population pharmacokinetics (PPKs). A PPK model for cefprozil will be a great advantage for clinical use. Thus, the aim of this study was to develop a PPK model for cefprozil for healthy male Koreans. Clinical PK and demographic data of healthy Korean males receiving cefprozil at a dose of 1000 mg were analyzed using Phoenix<sup>®</sup> NLME™. A one-compartment model with first-order absorption with lag-time was constructed as a base model. The model was extended to include covariates that influenced between-subject variability. Creatinine clearance significantly influenced systemic clearance of cefprozil. The final PPK model for <i>cis</i>-, <i>trans</i>-, and total cefprozil was established and validated. PPK parameter values of <i>cis</i>- and total cefprozil were similar to each other, but different from those of <i>trans</i>-isomer. Herein, we describe the establishment of accurate PPK models of <i>cis</i>-, <i>trans</i>-, and total cefprozil for healthy male Koreans for the first time. It may be useful as a dosing algorithm for the general population. These results might also contribute to the development of stereoisomeric cefprozil.https://www.mdpi.com/1999-4923/11/10/531cefprozilpopulation pharmacokineticsmodeling<i>cis</i>- and <i>trans</i>-isomers |
| spellingShingle | Ji-Hun Jang Seung-Hyun Jeong Hea-Young Cho Yong-Bok Lee Population Pharmacokinetics of <i>Cis</i>-, <i>Trans</i>-, and Total Cefprozil in Healthy Male Koreans Pharmaceutics cefprozil population pharmacokinetics modeling <i>cis</i>- and <i>trans</i>-isomers |
| title | Population Pharmacokinetics of <i>Cis</i>-, <i>Trans</i>-, and Total Cefprozil in Healthy Male Koreans |
| title_full | Population Pharmacokinetics of <i>Cis</i>-, <i>Trans</i>-, and Total Cefprozil in Healthy Male Koreans |
| title_fullStr | Population Pharmacokinetics of <i>Cis</i>-, <i>Trans</i>-, and Total Cefprozil in Healthy Male Koreans |
| title_full_unstemmed | Population Pharmacokinetics of <i>Cis</i>-, <i>Trans</i>-, and Total Cefprozil in Healthy Male Koreans |
| title_short | Population Pharmacokinetics of <i>Cis</i>-, <i>Trans</i>-, and Total Cefprozil in Healthy Male Koreans |
| title_sort | population pharmacokinetics of i cis i i trans i and total cefprozil in healthy male koreans |
| topic | cefprozil population pharmacokinetics modeling <i>cis</i>- and <i>trans</i>-isomers |
| url | https://www.mdpi.com/1999-4923/11/10/531 |
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