Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation
Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wo...
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| Format: | Article |
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MDPI AG
2017-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/18/8/1819 |
| _version_ | 1811264764629745664 |
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| author | Yvonne Reinders Oliver Felthaus Gero Brockhoff Fabian Pohl Norbert Ahrens Lukas Prantl Frank Haubner |
| author_facet | Yvonne Reinders Oliver Felthaus Gero Brockhoff Fabian Pohl Norbert Ahrens Lukas Prantl Frank Haubner |
| author_sort | Yvonne Reinders |
| collection | DOAJ |
| description | Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma. |
| first_indexed | 2024-04-12T20:10:11Z |
| format | Article |
| id | doaj.art-6b59766692df4979b85e9c24905592fc |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T20:10:11Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6b59766692df4979b85e9c24905592fc2022-12-22T03:18:17ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-08-01188181910.3390/ijms18081819ijms18081819Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External RadiationYvonne Reinders0Oliver Felthaus1Gero Brockhoff2Fabian Pohl3Norbert Ahrens4Lukas Prantl5Frank Haubner6Department of Otorhinolaryngology, Division of Facial Plastic Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Plastic, Aesthetic, Hand & Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Gynaecology and Obstetrics, University Medical Centre Regensburg, 93053 Regensburg, GermanyDepartment of Radiotherapy, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Plastic, Aesthetic, Hand & Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Otorhinolaryngology, Division of Facial Plastic Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyPlatelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma.https://www.mdpi.com/1422-0067/18/8/1819radiation therapyhuman adipose-derived stem cellsmicrovascular endothelial cellsplatelet-rich plasma |
| spellingShingle | Yvonne Reinders Oliver Felthaus Gero Brockhoff Fabian Pohl Norbert Ahrens Lukas Prantl Frank Haubner Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation International Journal of Molecular Sciences radiation therapy human adipose-derived stem cells microvascular endothelial cells platelet-rich plasma |
| title | Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation |
| title_full | Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation |
| title_fullStr | Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation |
| title_full_unstemmed | Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation |
| title_short | Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation |
| title_sort | impact of platelet rich plasma on viability and proliferation in wound healing processes after external radiation |
| topic | radiation therapy human adipose-derived stem cells microvascular endothelial cells platelet-rich plasma |
| url | https://www.mdpi.com/1422-0067/18/8/1819 |
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