Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty?
Protein tyrosine phosphatases, together with protein tyrosine kinases, control many molecular signaling steps that control life at cellular and organismal levels. Impairing alterations in the genes encoding the involved proteins is expected to profoundly affect the quality of life—if compatible with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1051311/full |
| _version_ | 1828056459284316160 |
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| author | Wiljan J. A. J. Hendriks Remco T. P. van Cruchten Rafael Pulido Rafael Pulido |
| author_facet | Wiljan J. A. J. Hendriks Remco T. P. van Cruchten Rafael Pulido Rafael Pulido |
| author_sort | Wiljan J. A. J. Hendriks |
| collection | DOAJ |
| description | Protein tyrosine phosphatases, together with protein tyrosine kinases, control many molecular signaling steps that control life at cellular and organismal levels. Impairing alterations in the genes encoding the involved proteins is expected to profoundly affect the quality of life—if compatible with life at all. Here, we review the current knowledge on the effects of germline variants that have been reported for genes encoding a subset of the protein tyrosine phosphatase superfamily; that of the thirty seven classical members. The conclusion must be that the newest genome research tools produced an avalanche of data that suggest ‘guilt by association’ for individual genes to specific disorders. Future research should face the challenge to investigate these accusations thoroughly and convincingly, to reach a mature genotype-phenotype map for this intriguing protein family. |
| first_indexed | 2024-04-10T20:54:37Z |
| format | Article |
| id | doaj.art-6b5a71ea29cb4af58de81ce720b5b8d8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T20:54:37Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6b5a71ea29cb4af58de81ce720b5b8d82023-01-23T07:02:19ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-01-011010.3389/fcell.2022.10513111051311Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty?Wiljan J. A. J. Hendriks0Remco T. P. van Cruchten1Rafael Pulido2Rafael Pulido3Department of Cell Biology, Radboud University Medical Centre, Nijmegen, The NetherlandsDepartment of Pathology, Radboud University Medical Centre, Nijmegen, The NetherlandsBiomarkers in Cancer Unit, Biocruces Bizkaia Health Research Institute, Barakaldo, SpainIkerbasque, Basque Foundation for Science, Bilbao, SpainProtein tyrosine phosphatases, together with protein tyrosine kinases, control many molecular signaling steps that control life at cellular and organismal levels. Impairing alterations in the genes encoding the involved proteins is expected to profoundly affect the quality of life—if compatible with life at all. Here, we review the current knowledge on the effects of germline variants that have been reported for genes encoding a subset of the protein tyrosine phosphatase superfamily; that of the thirty seven classical members. The conclusion must be that the newest genome research tools produced an avalanche of data that suggest ‘guilt by association’ for individual genes to specific disorders. Future research should face the challenge to investigate these accusations thoroughly and convincingly, to reach a mature genotype-phenotype map for this intriguing protein family.https://www.frontiersin.org/articles/10.3389/fcell.2022.1051311/fulldisease susceptibilitygene mutationhereditable diseasephosphotyrosineposttranslational modificationsignal transduction |
| spellingShingle | Wiljan J. A. J. Hendriks Remco T. P. van Cruchten Rafael Pulido Rafael Pulido Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty? Frontiers in Cell and Developmental Biology disease susceptibility gene mutation hereditable disease phosphotyrosine posttranslational modification signal transduction |
| title | Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty? |
| title_full | Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty? |
| title_fullStr | Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty? |
| title_full_unstemmed | Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty? |
| title_short | Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty? |
| title_sort | hereditable variants of classical protein tyrosine phosphatase genes will they prove innocent or guilty |
| topic | disease susceptibility gene mutation hereditable disease phosphotyrosine posttranslational modification signal transduction |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1051311/full |
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