Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia
Background &Objective: Plaryngoscopy and tracheal intubation increase not only blood pressure and heart rate but also Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and during general anesthesia followed by mexiletine pr...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Fasa University of Medical Sciences
2014-09-01
|
| Series: | Journal of Fasa University of Medical Sciences |
| Subjects: | |
| Online Access: | http://journal.fums.ac.ir/browse.php?a_code=A-10-60-2&slc_lang=en&sid=1 |
| _version_ | 1818113359327789056 |
|---|---|
| author | mohammad ali haghbin hamid khosro zamiri marjan shahabi mohammad shabani hamed vahdani |
| author_facet | mohammad ali haghbin hamid khosro zamiri marjan shahabi mohammad shabani hamed vahdani |
| author_sort | mohammad ali haghbin |
| collection | DOAJ |
| description | Background &Objective: Plaryngoscopy and
tracheal intubation increase not only blood pressure and heart rate but also
Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and
during general anesthesia followed by mexiletine prescription .
Materials & Methods: In this study, 50
patients aged between 20 and 60 who were candidates for orthopedic surgery of
the upper limbs were surveyed. They were divided in two groups randomly. Two
hours before induction of anesthesia, case
and control groups received mexiletine 200 mg as capsule and oral placebo,
respectively. Systolic and diastolic blood pressures ,heart rate,
and BIS of both groups were compared before induction and intubation; 1,3 and
10 minutes after intubation; and immediately
, 15, 30, 45, and 60 minutes
after surgical incision.
Results: There was not any significant differences in systolic and
diastolic pressures of the two groups. The heart rate was lower in mexiletine group
compared to control group, 30 minutes after surgical incision and immediately
after extubation (P<0.05). BIS
was significantly more in mexiletine groupcompared to control group
(p<0/05).
Conclusion: It was revealed that
the hemodynamic changes after laryngoscopy and during general anesthesia
were significantly lower in mexiletine group compared to the control group. It`s suggested that the prescription
of this drug leads to the increase of BIS after intubation and during general
anesthesia. |
| first_indexed | 2024-12-11T03:33:35Z |
| format | Article |
| id | doaj.art-6b5b00e62ac045c1b3000053e6bead48 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2228-7329 |
| language | fas |
| last_indexed | 2024-12-11T03:33:35Z |
| publishDate | 2014-09-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Fasa University of Medical Sciences |
| spelling | doaj.art-6b5b00e62ac045c1b3000053e6bead482022-12-22T01:22:18ZfasFasa University of Medical SciencesJournal of Fasa University of Medical Sciences2228-51052228-73292014-09-0142243250Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesiamohammad ali haghbin0hamid khosro zamiri1marjan shahabi2mohammad shabani3hamed vahdani4 Department of Anesthesiology, Neurology Research Center, Kerman University Of Medical Science, Kerman, Iran Department of Anesthesiology, Kerman University of Medical Science, Kerman, Iran Department of Anesthesiology, Kerman University of Medical Science, Kerman, Iran Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Science, Kerman, Iran Kerman Health Center, Kerman University of Medical Science, Kerman, Iran Background &Objective: Plaryngoscopy and tracheal intubation increase not only blood pressure and heart rate but also Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and during general anesthesia followed by mexiletine prescription . Materials & Methods: In this study, 50 patients aged between 20 and 60 who were candidates for orthopedic surgery of the upper limbs were surveyed. They were divided in two groups randomly. Two hours before induction of anesthesia, case and control groups received mexiletine 200 mg as capsule and oral placebo, respectively. Systolic and diastolic blood pressures ,heart rate, and BIS of both groups were compared before induction and intubation; 1,3 and 10 minutes after intubation; and immediately , 15, 30, 45, and 60 minutes after surgical incision. Results: There was not any significant differences in systolic and diastolic pressures of the two groups. The heart rate was lower in mexiletine group compared to control group, 30 minutes after surgical incision and immediately after extubation (P<0.05). BIS was significantly more in mexiletine groupcompared to control group (p<0/05). Conclusion: It was revealed that the hemodynamic changes after laryngoscopy and during general anesthesia were significantly lower in mexiletine group compared to the control group. It`s suggested that the prescription of this drug leads to the increase of BIS after intubation and during general anesthesia.http://journal.fums.ac.ir/browse.php?a_code=A-10-60-2&slc_lang=en&sid=1Mexiletine Bispectral Index (BIS) Hemodynamic Changes Laryngoscopy and Tracheal Intubation |
| spellingShingle | mohammad ali haghbin hamid khosro zamiri marjan shahabi mohammad shabani hamed vahdani Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia Journal of Fasa University of Medical Sciences Mexiletine Bispectral Index (BIS) Hemodynamic Changes Laryngoscopy and Tracheal Intubation |
| title | Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia |
| title_full | Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia |
| title_fullStr | Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia |
| title_full_unstemmed | Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia |
| title_short | Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia |
| title_sort | evaluation of mexiletine effect on bispectral index changes and hemodynamic responses to endotracheal intubation and during general anesthesia |
| topic | Mexiletine Bispectral Index (BIS) Hemodynamic Changes Laryngoscopy and Tracheal Intubation |
| url | http://journal.fums.ac.ir/browse.php?a_code=A-10-60-2&slc_lang=en&sid=1 |
| work_keys_str_mv | AT mohammadalihaghbin evaluationofmexiletineeffectonbispectralindexchangesandhemodynamicresponsestoendotrachealintubationandduringgeneralanesthesia AT hamidkhosrozamiri evaluationofmexiletineeffectonbispectralindexchangesandhemodynamicresponsestoendotrachealintubationandduringgeneralanesthesia AT marjanshahabi evaluationofmexiletineeffectonbispectralindexchangesandhemodynamicresponsestoendotrachealintubationandduringgeneralanesthesia AT mohammadshabani evaluationofmexiletineeffectonbispectralindexchangesandhemodynamicresponsestoendotrachealintubationandduringgeneralanesthesia AT hamedvahdani evaluationofmexiletineeffectonbispectralindexchangesandhemodynamicresponsestoendotrachealintubationandduringgeneralanesthesia |