Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>”
The genus <i>Pestivirus</i> of the family <i>Flaviviridae</i> mainly comprises classical swine fever virus (CSFV), bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, border disease virus (BDV), and multiple new pestivirus species such as atypical porcine pestivirus (APPV), giraf...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/1/2 |
| _version_ | 1797436546134048768 |
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| author | Mengqi Yuan Xiaoke Yang Xin Zhang Xiaotian Zhao Muhammad Abid Hua-Ji Qiu Yongfeng Li |
| author_facet | Mengqi Yuan Xiaoke Yang Xin Zhang Xiaotian Zhao Muhammad Abid Hua-Ji Qiu Yongfeng Li |
| author_sort | Mengqi Yuan |
| collection | DOAJ |
| description | The genus <i>Pestivirus</i> of the family <i>Flaviviridae</i> mainly comprises classical swine fever virus (CSFV), bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, border disease virus (BDV), and multiple new pestivirus species such as atypical porcine pestivirus (APPV), giraffe pestivirus, and antelope pestivirus. Pestiviruses cause infectious diseases, resulting in tremendous economic losses to animal husbandry. Different types of pestivirus vaccines have been developed to control and prevent these important animal diseases. In recent years, pestiviruses have shown great potential as viral vectors for developing multivalent vaccines. This review analyzes the advantages and disadvantages of various pestivirus vaccines, including live attenuated pestivirus strains, genetically engineered marker pestiviruses, and pestivirus-based multivalent vaccines. This review provides new insights into the development of novel vaccines against emerging pestiviruses, such as APPV and ovine pestivirus. |
| first_indexed | 2024-03-09T11:03:17Z |
| format | Article |
| id | doaj.art-6b5b780a2b7d4e1b87a436a602a877e6 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T11:03:17Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-6b5b780a2b7d4e1b87a436a602a877e62023-12-01T01:05:48ZengMDPI AGViruses1999-49152022-12-01151210.3390/v15010002Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>”Mengqi Yuan0Xiaoke Yang1Xin Zhang2Xiaotian Zhao3Muhammad Abid4Hua-Ji Qiu5Yongfeng Li6State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaViral Oncogenesis Group, The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UKState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaThe genus <i>Pestivirus</i> of the family <i>Flaviviridae</i> mainly comprises classical swine fever virus (CSFV), bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, border disease virus (BDV), and multiple new pestivirus species such as atypical porcine pestivirus (APPV), giraffe pestivirus, and antelope pestivirus. Pestiviruses cause infectious diseases, resulting in tremendous economic losses to animal husbandry. Different types of pestivirus vaccines have been developed to control and prevent these important animal diseases. In recent years, pestiviruses have shown great potential as viral vectors for developing multivalent vaccines. This review analyzes the advantages and disadvantages of various pestivirus vaccines, including live attenuated pestivirus strains, genetically engineered marker pestiviruses, and pestivirus-based multivalent vaccines. This review provides new insights into the development of novel vaccines against emerging pestiviruses, such as APPV and ovine pestivirus.https://www.mdpi.com/1999-4915/15/1/2pestiviruseslive attenuated vaccinesmarker vaccinesmultivalent vaccines |
| spellingShingle | Mengqi Yuan Xiaoke Yang Xin Zhang Xiaotian Zhao Muhammad Abid Hua-Ji Qiu Yongfeng Li Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>” Viruses pestiviruses live attenuated vaccines marker vaccines multivalent vaccines |
| title | Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>” |
| title_full | Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>” |
| title_fullStr | Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>” |
| title_full_unstemmed | Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>” |
| title_short | Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>” |
| title_sort | different types of vaccines against pestiviral infections barriers for i pestis i |
| topic | pestiviruses live attenuated vaccines marker vaccines multivalent vaccines |
| url | https://www.mdpi.com/1999-4915/15/1/2 |
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