SARS-CoV-2 N protein induced acute kidney injury in diabetic db/db mice is associated with a Mincle-dependent M1 macrophage activation

SARS-CoV-2 N protein induced acute kidney injury in diabetic db/db mice is associated with a Mincle-dependent M1 macrophage activation

“Cytokine storm” is common in critically ill COVID-19 patients, however, mechanisms remain largely unknown. Here, we reported that overexpression of SARS-CoV-2 N protein in diabetic db/db mice significantly increased tubular death and the release of HMGB1, one of the damage-associated molecular patt...

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Bibliographic Details
Main Authors: Wenjing Wu, Wenbiao Wang, Liying Liang, Junzhe Chen, Sifan Sun, Biao Wei, Yu Zhong, Xiao-Ru Huang, Jian Liu, Xiaoqin Wang, Xueqing Yu, Hui-Yao Lan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
N protein
AKI
quercetin
Mincle
M1 macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1264447/full

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