Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot Study
<i>Background and objectives</i>: Diabetes may affect in-hospital mortality of patients with Coronavirus disease 2019 (COVID-19). We have retrospectively evaluated clinical characteristics, diabetes management, and outcomes in a sample of COVID-19 patients with diabetes admitted to our h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/4/341 |
| _version_ | 1797539110402916352 |
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| author | Marco Ricchio Bruno Tassone Maria Chiara Pelle Maria Mazzitelli Francesca Serapide Paolo Fusco Rosaria Lionello Anna Cancelliere Giada Procopio Elena Lio Enrico Maria Trecarichi Carlo Torti Concetta Irace |
| author_facet | Marco Ricchio Bruno Tassone Maria Chiara Pelle Maria Mazzitelli Francesca Serapide Paolo Fusco Rosaria Lionello Anna Cancelliere Giada Procopio Elena Lio Enrico Maria Trecarichi Carlo Torti Concetta Irace |
| author_sort | Marco Ricchio |
| collection | DOAJ |
| description | <i>Background and objectives</i>: Diabetes may affect in-hospital mortality of patients with Coronavirus disease 2019 (COVID-19). We have retrospectively evaluated clinical characteristics, diabetes management, and outcomes in a sample of COVID-19 patients with diabetes admitted to our hospital. <i>Materials and Methods</i>: All patients admitted to the Infectious Diseases Unit from 28 March 2020, to 16 June 2020, were enrolled. Clinical information and biochemical parameters were collected at the time of admission. Patients were ranked according to diabetes and death. <i>Results</i>: Sixty-one patients with COVID-19 were analyzed. Most of them were from a long-term health care facility. Mean age was 77 ± 16 years, and 19 had type 2 diabetes (T2D). Eighteen patients died, including 8 with T2D and 10 without T2D (<i>p</i> = 0.15). Patients with diabetes were significantly older, had a higher prevalence of cardiovascular diseases, and a significantly lower lymphocyte count. No significant relationship was found between diabetes and in-hospital mortality (Odds Ratio OR 2.3; Confidence Interval CI 0.73–7.38, <i>p</i> = 0.15). Patients with diabetes were treated with insulin titration algorithm. Severe hypoglycemic events, ketoacidosis and hyperosmolar hyperglycemias did not occur during hospitalization. Mean pre-meal capillary blood glucose was 157 ± 45 mg/dL, and the coefficient of variation of glycaemia was 29%. <i>Conclusions</i>: Our study, albeit limited by the small number of subjects, did not describe any significant association between T2D diabetes and mortality. Clinical characteristics of patients, and acceptable glucose control prior and during hospitalization may have influenced the result. The use of an insulin titration algorithm should be pursued during hospitalization. |
| first_indexed | 2024-03-10T12:40:38Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T12:40:38Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-6b5c6e317acd4b388a2a52ae3bf1ab0e2023-11-21T13:52:58ZengMDPI AGMedicina1010-660X1648-91442021-04-0157434110.3390/medicina57040341Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot StudyMarco Ricchio0Bruno Tassone1Maria Chiara Pelle2Maria Mazzitelli3Francesca Serapide4Paolo Fusco5Rosaria Lionello6Anna Cancelliere7Giada Procopio8Elena Lio9Enrico Maria Trecarichi10Carlo Torti11Concetta Irace12Azienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyAzienda Ospedaliero-Universitaria Mater Domini, University Magna Graecia, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University Magna Graecia, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University Magna Graecia, 88100 Catanzaro, ItalyDepartment of Health Science, University Magna Graecia, 88100 Catanzaro, Italy<i>Background and objectives</i>: Diabetes may affect in-hospital mortality of patients with Coronavirus disease 2019 (COVID-19). We have retrospectively evaluated clinical characteristics, diabetes management, and outcomes in a sample of COVID-19 patients with diabetes admitted to our hospital. <i>Materials and Methods</i>: All patients admitted to the Infectious Diseases Unit from 28 March 2020, to 16 June 2020, were enrolled. Clinical information and biochemical parameters were collected at the time of admission. Patients were ranked according to diabetes and death. <i>Results</i>: Sixty-one patients with COVID-19 were analyzed. Most of them were from a long-term health care facility. Mean age was 77 ± 16 years, and 19 had type 2 diabetes (T2D). Eighteen patients died, including 8 with T2D and 10 without T2D (<i>p</i> = 0.15). Patients with diabetes were significantly older, had a higher prevalence of cardiovascular diseases, and a significantly lower lymphocyte count. No significant relationship was found between diabetes and in-hospital mortality (Odds Ratio OR 2.3; Confidence Interval CI 0.73–7.38, <i>p</i> = 0.15). Patients with diabetes were treated with insulin titration algorithm. Severe hypoglycemic events, ketoacidosis and hyperosmolar hyperglycemias did not occur during hospitalization. Mean pre-meal capillary blood glucose was 157 ± 45 mg/dL, and the coefficient of variation of glycaemia was 29%. <i>Conclusions</i>: Our study, albeit limited by the small number of subjects, did not describe any significant association between T2D diabetes and mortality. Clinical characteristics of patients, and acceptable glucose control prior and during hospitalization may have influenced the result. The use of an insulin titration algorithm should be pursued during hospitalization.https://www.mdpi.com/1648-9144/57/4/341Covid-19diabetesmortalityinsulin therapy |
| spellingShingle | Marco Ricchio Bruno Tassone Maria Chiara Pelle Maria Mazzitelli Francesca Serapide Paolo Fusco Rosaria Lionello Anna Cancelliere Giada Procopio Elena Lio Enrico Maria Trecarichi Carlo Torti Concetta Irace Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot Study Medicina Covid-19 diabetes mortality insulin therapy |
| title | Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot Study |
| title_full | Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot Study |
| title_fullStr | Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot Study |
| title_full_unstemmed | Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot Study |
| title_short | Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot Study |
| title_sort | characteristics management and outcomes of elderly patients with diabetes in a covid 19 unit lessons learned from a pilot study |
| topic | Covid-19 diabetes mortality insulin therapy |
| url | https://www.mdpi.com/1648-9144/57/4/341 |
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