APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress

APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress

Polymorphisms in the Apolipoprotein L1 (APOL1) gene are common in ancestrally African populations, and associate with kidney injury and cardiovascular disease. These risk variants (RV) provide an advantage in resisting Trypanosoma brucei, the causal agent of African trypanosomiasis, and are largely...

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Bibliographic Details
Main Authors: Ashira Blazer, Yingzhi Qian, Martin Paul Schlegel, Huda Algasas, Jill P. Buyon, Ken Cadwell, Michael Cammer, Sean P. Heffron, Feng-Xia Liang, Shilpi Mehta-Lee, Timothy Niewold, Sara E. Rasmussen, Robert M. Clancy
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
APOL1
Autophagy
Mitochondria
HUVECs
interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.769936/full

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