The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBM
In this study, we observed pediatric complete spinal cord injury (CSCI) patients receiving MI training and divided them into different groups according to the effect of motor imagery (MI) training on neuropathic pain (NP). Then, we retrospectively analysed the differences in brain structure of these...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024006005 |
| _version_ | 1797328600557420544 |
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| author | Ling Wang Xin Chen Weimin Zheng Yanhui Yang Beining Yang Qian Chen Xuejing Li Tengfei Liang Baowei Li Yongsheng Hu Jubao Du Jie Lu Nan Chen |
| author_facet | Ling Wang Xin Chen Weimin Zheng Yanhui Yang Beining Yang Qian Chen Xuejing Li Tengfei Liang Baowei Li Yongsheng Hu Jubao Du Jie Lu Nan Chen |
| author_sort | Ling Wang |
| collection | DOAJ |
| description | In this study, we observed pediatric complete spinal cord injury (CSCI) patients receiving MI training and divided them into different groups according to the effect of motor imagery (MI) training on neuropathic pain (NP). Then, we retrospectively analysed the differences in brain structure of these groups before the MI training, identifying brain regions that may predict the effect of MI on NP. Thirty pediatric CSCI patients were included, including 12 patients who experienced NP during MI and 18 patients who did not experience NP during MI according to the MI training follow‐up. The 3D high-resolution T1-weighted images of all subjects were obtained using a 3.0 T MRI system before MI training. A two-sample t-test was performed to evaluate the differences in gray matter volume (GMV) between patients who experienced NP and those who did not experience NP during MI. Receiver operating characteristic (ROC) analysis was performed to compute the sensitivity and specificity of the imaging biomarkers for the effect of MI on NP in pediatric CSCI patients. MI evoked NP in some of the pediatric CSCI patients. Compared with patients who did not experience NP, patients who experienced NP during MI showed larger GMV in the right primary sensorimotor cortex (PSMC) and insula. When using the GMV of the right PSMC and insula in combination as a predictor, the area under the curve (AUC) reached 0.824. Our study demonstrated that MI could evoke NP in some pediatric CSCI patients, but not in others. The individual differences in brain reorganization of the right PSMC and insula may contribute to the different effects of MI on NP. Moreover, the GMV of the right PSMC and insula in combination may be an effective indicator for screening pediatric CSCI patients before MI training therapy. |
| first_indexed | 2024-03-08T06:54:57Z |
| format | Article |
| id | doaj.art-6b5dd73130eb48609bcf3aa055d0730d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:54:57Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6b5dd73130eb48609bcf3aa055d0730d2024-02-03T06:37:53ZengElsevierHeliyon2405-84402024-01-01102e24569The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBMLing Wang0Xin Chen1Weimin Zheng2Yanhui Yang3Beining Yang4Qian Chen5Xuejing Li6Tengfei Liang7Baowei Li8Yongsheng Hu9Jubao Du10Jie Lu11Nan Chen12Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, 100053, ChinaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, 100053, ChinaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, 100053, ChinaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, 100053, ChinaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, 100053, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, ChinaDepartment of Radiology, China Rehabilitation Research Center, Beijing, 100068, ChinaDepartment of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, 056008, ChinaDepartment of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, 056008, ChinaDepartment of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, ChinaDepartment of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, ChinaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, 100053, ChinaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, 100053, China; Corresponding author. Department of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No. 45 Chang-chun St., Xicheng District, Beijing, China.In this study, we observed pediatric complete spinal cord injury (CSCI) patients receiving MI training and divided them into different groups according to the effect of motor imagery (MI) training on neuropathic pain (NP). Then, we retrospectively analysed the differences in brain structure of these groups before the MI training, identifying brain regions that may predict the effect of MI on NP. Thirty pediatric CSCI patients were included, including 12 patients who experienced NP during MI and 18 patients who did not experience NP during MI according to the MI training follow‐up. The 3D high-resolution T1-weighted images of all subjects were obtained using a 3.0 T MRI system before MI training. A two-sample t-test was performed to evaluate the differences in gray matter volume (GMV) between patients who experienced NP and those who did not experience NP during MI. Receiver operating characteristic (ROC) analysis was performed to compute the sensitivity and specificity of the imaging biomarkers for the effect of MI on NP in pediatric CSCI patients. MI evoked NP in some of the pediatric CSCI patients. Compared with patients who did not experience NP, patients who experienced NP during MI showed larger GMV in the right primary sensorimotor cortex (PSMC) and insula. When using the GMV of the right PSMC and insula in combination as a predictor, the area under the curve (AUC) reached 0.824. Our study demonstrated that MI could evoke NP in some pediatric CSCI patients, but not in others. The individual differences in brain reorganization of the right PSMC and insula may contribute to the different effects of MI on NP. Moreover, the GMV of the right PSMC and insula in combination may be an effective indicator for screening pediatric CSCI patients before MI training therapy.http://www.sciencedirect.com/science/article/pii/S2405844024006005Motor imageryNeuropathic painPediatric complete spinal cord injuryMagnetic resonance imagingVoxel based morphometry |
| spellingShingle | Ling Wang Xin Chen Weimin Zheng Yanhui Yang Beining Yang Qian Chen Xuejing Li Tengfei Liang Baowei Li Yongsheng Hu Jubao Du Jie Lu Nan Chen The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBM Heliyon Motor imagery Neuropathic pain Pediatric complete spinal cord injury Magnetic resonance imaging Voxel based morphometry |
| title | The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBM |
| title_full | The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBM |
| title_fullStr | The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBM |
| title_full_unstemmed | The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBM |
| title_short | The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBM |
| title_sort | possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury a preliminary brain structure study based on vbm |
| topic | Motor imagery Neuropathic pain Pediatric complete spinal cord injury Magnetic resonance imaging Voxel based morphometry |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024006005 |
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