The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke
Objective: Inflammation and migration of leukocytes to the brain parenchyma play a role in atherosclerosis and cerebral ischemic stroke. Migration occurs with the help of adhesion molecules on the surface of cerebral endothelial cells and leukocytes. P-selectin, an adhesion molecule, is present on t...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2020-03-01
|
| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-26096 |
| _version_ | 1797910846757666816 |
|---|---|
| author | Dilek Yılmaz Seda Aladağ Kurt Aslıhan Onay Resul Karakuş Belgin Koçer |
| author_facet | Dilek Yılmaz Seda Aladağ Kurt Aslıhan Onay Resul Karakuş Belgin Koçer |
| author_sort | Dilek Yılmaz |
| collection | DOAJ |
| description | Objective: Inflammation and migration of leukocytes to the brain parenchyma play a role in atherosclerosis and cerebral ischemic stroke. Migration occurs with the help of adhesion molecules on the surface of cerebral endothelial cells and leukocytes. P-selectin, an adhesion molecule, is present on the platelet and endothelial surface and allows leukocytes to loosely adhere to the endothelium, and its increase has been shown in acute ischemic stroke (AIS). Thrombin-activatable fibrinolysis inhibitor (TAFI) is a procarboxypeptidase molecule that can be another marker of AIS, which has been shown to increase the risk of thromboembolism and stroke 6-fold. Intima-media thickness (IMT) is thought to be associated with atherosclerotic diseases in carotid ultrasonography (USG) and increased risk of ischemic stroke has been found to be associated with increased carotid IMT. In this study, we investigated the relationship between P-selectin and TAFI levels, which have been shown to be effective for AIS via carotid IMT, and is considered significant for atherosclerosis.
Materials and Methods: Forty patients with AIS and 22 healthy subjects were included in the study. In both groups, serum P-selectin and TAFI levels were studied at the time of presentation, and on day 7, day 14, and at one month; carotid IMT and stenosis rates were measured by Doppler USG. P-selectin and TAFI levels were compared with carotid IMT in both groups.
Results: There was no significant difference between P-selectin levels and carotid IMT between the groups; TAFI levels were significantly higher in the patient group and were correlated with carotid IMT in both groups.
Conclusion: TAFI increase has been suggested to be a marker of early atherosclerosis in asymptomatic atherosclerosis and ischemic stroke. A positive correlation between TAFI levels and carotid IMT and stenosis rates have been reported; however, the positive correlation between increased P-selectin levels in AIS and carotid IMT was not detected in our study. |
| first_indexed | 2024-04-10T11:31:03Z |
| format | Article |
| id | doaj.art-6b620d77a343454fa76ba6a6075decbc |
| institution | Directory Open Access Journal |
| issn | 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T11:31:03Z |
| publishDate | 2020-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-6b620d77a343454fa76ba6a6075decbc2023-02-15T16:18:07ZengGalenos YayineviTürk Nöroloji Dergisi1309-25452020-03-01261192310.4274/tnd.galenos.2019.26096The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic StrokeDilek Yılmaz0https://orcid.org/0000-0002-9653-3009Seda Aladağ Kurt1https://orcid.org/0000-0002-5822-888XAslıhan Onay2https://orcid.org/0000-0003-4213-9126Resul Karakuş3https://orcid.org/0000-0003-2654-6119Belgin Koçer4https://orcid.org/0000-0003-2580-9650Konya Numune State Hospital, Clinic of Neurology, Konya, TurkeyIstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Radiology, Istanbul, TurkeyBaskent University Faculty of Medicine, Department of Radiology, Ankara, TurkeyGazi University Faculty of Medicine, Department of Microbiyology, Ankara, TurkeyGazi University Faculty of Medicine, Department of Neurology, Ankara, TurkeyObjective: Inflammation and migration of leukocytes to the brain parenchyma play a role in atherosclerosis and cerebral ischemic stroke. Migration occurs with the help of adhesion molecules on the surface of cerebral endothelial cells and leukocytes. P-selectin, an adhesion molecule, is present on the platelet and endothelial surface and allows leukocytes to loosely adhere to the endothelium, and its increase has been shown in acute ischemic stroke (AIS). Thrombin-activatable fibrinolysis inhibitor (TAFI) is a procarboxypeptidase molecule that can be another marker of AIS, which has been shown to increase the risk of thromboembolism and stroke 6-fold. Intima-media thickness (IMT) is thought to be associated with atherosclerotic diseases in carotid ultrasonography (USG) and increased risk of ischemic stroke has been found to be associated with increased carotid IMT. In this study, we investigated the relationship between P-selectin and TAFI levels, which have been shown to be effective for AIS via carotid IMT, and is considered significant for atherosclerosis. Materials and Methods: Forty patients with AIS and 22 healthy subjects were included in the study. In both groups, serum P-selectin and TAFI levels were studied at the time of presentation, and on day 7, day 14, and at one month; carotid IMT and stenosis rates were measured by Doppler USG. P-selectin and TAFI levels were compared with carotid IMT in both groups. Results: There was no significant difference between P-selectin levels and carotid IMT between the groups; TAFI levels were significantly higher in the patient group and were correlated with carotid IMT in both groups. Conclusion: TAFI increase has been suggested to be a marker of early atherosclerosis in asymptomatic atherosclerosis and ischemic stroke. A positive correlation between TAFI levels and carotid IMT and stenosis rates have been reported; however, the positive correlation between increased P-selectin levels in AIS and carotid IMT was not detected in our study.http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-26096ischemic strokep-selectinthrombin-activatable fibrinolysis inhibitorcarotid intima-media thickness |
| spellingShingle | Dilek Yılmaz Seda Aladağ Kurt Aslıhan Onay Resul Karakuş Belgin Koçer The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke Türk Nöroloji Dergisi ischemic stroke p-selectin thrombin-activatable fibrinolysis inhibitor carotid intima-media thickness |
| title | The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke |
| title_full | The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke |
| title_fullStr | The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke |
| title_full_unstemmed | The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke |
| title_short | The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke |
| title_sort | relation between serum p selectin thrombin activatable fibrinolysis inhibitor levels and carotid artery intima media thickness in acute ischemic stroke |
| topic | ischemic stroke p-selectin thrombin-activatable fibrinolysis inhibitor carotid intima-media thickness |
| url | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-26096 |
| work_keys_str_mv | AT dilekyılmaz therelationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT sedaaladagkurt therelationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT aslıhanonay therelationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT resulkarakus therelationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT belginkocer therelationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT dilekyılmaz relationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT sedaaladagkurt relationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT aslıhanonay relationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT resulkarakus relationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke AT belginkocer relationbetweenserumpselectinthrombinactivatablefibrinolysisinhibitorlevelsandcarotidarteryintimamediathicknessinacuteischemicstroke |