Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
The association of thyroid hormone antibodies and glycolipid metabolism indicators with Type 2 diabetes mellitus (T2DM) was explored. As the disease worsens, the levels of thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb), and thyroid-stimulating hormone (TSH) was increased, and the...
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-12-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2023-0876 |
| _version_ | 1827398627720429568 |
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| author | Liu Xuefang Qiu Youyan Chen Dandan Xiong Jingni Xia Biwen Chen Caiqin Li Suyan |
| author_facet | Liu Xuefang Qiu Youyan Chen Dandan Xiong Jingni Xia Biwen Chen Caiqin Li Suyan |
| author_sort | Liu Xuefang |
| collection | DOAJ |
| description | The association of thyroid hormone antibodies and glycolipid metabolism indicators with Type 2 diabetes mellitus (T2DM) was explored. As the disease worsens, the levels of thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb), and thyroid-stimulating hormone (TSH) was increased, and the levels of total tri-iodothyronine (TT3) and total thyroxine (TT4) was decreased (P < 0.001). The severe, medium, and light group had higher level of high-density lipoprotein (HDL), lower level of total cholesterol (TC), low-density lipoprotein (LDL), glycosylated hemoglobin (HbA1c), triacylglycerol (TAG), and fasting blood sugar (FBG) than the control group (P ＜ 0.05). The level of HDL was lower in the severe group than the light group and the medium group, but the levels of TC, LDL, HbA1c, TAG, and FBG were increased with the progress of T2DM (P ＜ 0.001). The levels of TGAb, TPOAb, and TSH in patients with T2DM were positively correlated with the levels of TC, LDL, HbA1c, TAG, and FBG (P < 0.05), and were negatively correlated with HDL levels (P < 0.05). The life quality score was lower in the severe group than the light and the medium group (P < 0.001). Among the above indicators, the predictive value of TT3, TT4, and HbA1c in T2DM was better. Clinically, detecting the levels of thyroid hormone antibodies and glycolipid metabolism indicators had a certain predictive value for the severity of T2DM. |
| first_indexed | 2024-03-08T19:32:27Z |
| format | Article |
| id | doaj.art-6b62de967d77437a90c44e8655a1ea6f |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-03-08T19:32:27Z |
| publishDate | 2023-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-6b62de967d77437a90c44e8655a1ea6f2023-12-26T07:40:35ZengDe GruyterOpen Medicine2391-54632023-12-01181822710.1515/med-2023-0876Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetesLiu Xuefang0Qiu Youyan1Chen Dandan2Xiong Jingni3Xia Biwen4Chen Caiqin5Li Suyan6Department of Endocrinology, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou511300, Guangdong Province, PR ChinaDepartment of Endocrinology, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou511300, Guangdong Province, PR ChinaDepartment of Endocrinology, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou511300, Guangdong Province, PR ChinaDepartment of Endocrinology, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou511300, Guangdong Province, PR ChinaDepartment of Endocrinology, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou511300, Guangdong Province, PR ChinaDepartment of Endocrinology, The Fourth Affiliated Hospital of Guangzhou Medical University, No. 1, Guangming East Road, Zengjiang Street, Zengcheng District, Guangzhou511300, Guangdong Province, PR ChinaDepartment of Endocrinology, The Fourth Affiliated Hospital of Guangzhou Medical University, No. 1, Guangming East Road, Zengjiang Street, Zengcheng District, Guangzhou511300, Guangdong Province, PR ChinaThe association of thyroid hormone antibodies and glycolipid metabolism indicators with Type 2 diabetes mellitus (T2DM) was explored. As the disease worsens, the levels of thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb), and thyroid-stimulating hormone (TSH) was increased, and the levels of total tri-iodothyronine (TT3) and total thyroxine (TT4) was decreased (P < 0.001). The severe, medium, and light group had higher level of high-density lipoprotein (HDL), lower level of total cholesterol (TC), low-density lipoprotein (LDL), glycosylated hemoglobin (HbA1c), triacylglycerol (TAG), and fasting blood sugar (FBG) than the control group (P ＜ 0.05). The level of HDL was lower in the severe group than the light group and the medium group, but the levels of TC, LDL, HbA1c, TAG, and FBG were increased with the progress of T2DM (P ＜ 0.001). The levels of TGAb, TPOAb, and TSH in patients with T2DM were positively correlated with the levels of TC, LDL, HbA1c, TAG, and FBG (P < 0.05), and were negatively correlated with HDL levels (P < 0.05). The life quality score was lower in the severe group than the light and the medium group (P < 0.001). Among the above indicators, the predictive value of TT3, TT4, and HbA1c in T2DM was better. Clinically, detecting the levels of thyroid hormone antibodies and glycolipid metabolism indicators had a certain predictive value for the severity of T2DM.https://doi.org/10.1515/med-2023-0876type 2 diabetesthyroid hormoneantibodies to glucose and lipid metabolismquality of lifemonitoring value |
| spellingShingle | Liu Xuefang Qiu Youyan Chen Dandan Xiong Jingni Xia Biwen Chen Caiqin Li Suyan Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes Open Medicine type 2 diabetes thyroid hormone antibodies to glucose and lipid metabolism quality of life monitoring value |
| title | Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes |
| title_full | Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes |
| title_fullStr | Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes |
| title_full_unstemmed | Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes |
| title_short | Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes |
| title_sort | significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes |
| topic | type 2 diabetes thyroid hormone antibodies to glucose and lipid metabolism quality of life monitoring value |
| url | https://doi.org/10.1515/med-2023-0876 |
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