GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.

Truncating GLI3 mutations in Pallister-Hall Syndrome with renal malformation suggests a requirement for Hedgehog signaling during renal development. HH-dependent signaling increases levels of GLI transcriptional activators and decreases processing of GLI3 to a shorter transcriptional repressor. Prev...

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Bibliographic Details
Main Authors: Jason E Cain, Epshita Islam, Fiona Haxho, Lin Chen, Darren Bridgewater, Erica Nieuwenhuis, Chi-Chung Hui, Norman D Rosenblum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2754339?pdf=render

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