Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation

Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation

Corticothalamic axons express Contactin-2 (CNTN2/TAG-1), a neuronal recognition molecule of the immunoglobulin superfamily involved in neurogenesis, neurite outgrowth, and fasciculation. TAG-1, which is expressed transiently by cortical pyramidal neurons during embryonic development, has been shown...

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Bibliographic Details
Main Authors: Maria Eleni Kastriti, Aikaterini Stratigi, Dimitris Mariatos, Marina Theodosiou, Maria Savvaki, Michaela Kavkova, Kostas Theodorakis, Marina Vidaki, Tomas Zikmund, Jozef Kaiser, Igor Adameyko, Domna Karagogeos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CNTN2/TAG-1
corticofugal system
corticothalamic axons
anterior commissure
corpus callosum
central nervous system
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00454/full

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