CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
CHARGE syndrome that affects cerebellar development can be caused by haploinsufficiency of the chromatin remodeling enzyme CHD7; however the precise role of CHD7 remains unknown. Here the authors show CHD7 promotes chromatin accessibility and enhancer activity in granule cell precursors and regulate...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25846-3 |
| _version_ | 1818401932275875840 |
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| author | Naveen C. Reddy Shahriyar P. Majidi Lingchun Kong Mati Nemera Cole J. Ferguson Michael Moore Tassia M. Goncalves Hai-Kun Liu James A. J. Fitzpatrick Guoyan Zhao Tomoko Yamada Azad Bonni Harrison W. Gabel |
| author_facet | Naveen C. Reddy Shahriyar P. Majidi Lingchun Kong Mati Nemera Cole J. Ferguson Michael Moore Tassia M. Goncalves Hai-Kun Liu James A. J. Fitzpatrick Guoyan Zhao Tomoko Yamada Azad Bonni Harrison W. Gabel |
| author_sort | Naveen C. Reddy |
| collection | DOAJ |
| description | CHARGE syndrome that affects cerebellar development can be caused by haploinsufficiency of the chromatin remodeling enzyme CHD7; however the precise role of CHD7 remains unknown. Here the authors show CHD7 promotes chromatin accessibility and enhancer activity in granule cell precursors and regulates morphogenesis of the cerebellar cortex, where loss of CHD7 triggers cerebellar polymicrogyria. |
| first_indexed | 2024-12-14T08:00:19Z |
| format | Article |
| id | doaj.art-6b65df7f5b89436183b44caa5fad1079 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:00:19Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6b65df7f5b89436183b44caa5fad10792022-12-21T23:10:25ZengNature PortfolioNature Communications2041-17232021-09-0112111710.1038/s41467-021-25846-3CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellumNaveen C. Reddy0Shahriyar P. Majidi1Lingchun Kong2Mati Nemera3Cole J. Ferguson4Michael Moore5Tassia M. Goncalves6Hai-Kun Liu7James A. J. Fitzpatrick8Guoyan Zhao9Tomoko Yamada10Azad Bonni11Harrison W. Gabel12Department of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDivision of Molecular Neurogenetics, DKFZ-ZMBH Alliance, German Cancer Research Center Im Neunheimer Feld 280Department of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineCHARGE syndrome that affects cerebellar development can be caused by haploinsufficiency of the chromatin remodeling enzyme CHD7; however the precise role of CHD7 remains unknown. Here the authors show CHD7 promotes chromatin accessibility and enhancer activity in granule cell precursors and regulates morphogenesis of the cerebellar cortex, where loss of CHD7 triggers cerebellar polymicrogyria.https://doi.org/10.1038/s41467-021-25846-3 |
| spellingShingle | Naveen C. Reddy Shahriyar P. Majidi Lingchun Kong Mati Nemera Cole J. Ferguson Michael Moore Tassia M. Goncalves Hai-Kun Liu James A. J. Fitzpatrick Guoyan Zhao Tomoko Yamada Azad Bonni Harrison W. Gabel CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum Nature Communications |
| title | CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum |
| title_full | CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum |
| title_fullStr | CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum |
| title_full_unstemmed | CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum |
| title_short | CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum |
| title_sort | charge syndrome protein chd7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum |
| url | https://doi.org/10.1038/s41467-021-25846-3 |
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