Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation in vitro

Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation in vitro

Intestinal disease or surgical intervention results in local changes in tissue and host-derived factors triggering bacterial virulence. A key phenotype involved in impaired tissue healing is increased bacterial collagenase expression which degrades intestinal collagen. Antibiotic administration is i...

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Bibliographic Details
Main Authors: Dylan Nichols, Marja B. Pimentel, Fernando T. P. Borges, Sanjiv K. Hyoju, Fouad Teymour, Seok Hoon Hong, Olga Y. Zaborina, John C. Alverdy, Georgia Papavasiliou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
polyphosphate
nanoparticles
hydrogel
microbes
collagenase
intestinal epithelium
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00153/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2019.00153/full

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