Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary
The vertebrate skull varies widely in shape, accommodating diverse strategies of feeding and predation. The braincase is composed of several flat bones that meet at flexible joints called sutures. Nearly all vertebrates have a prominent ‘coronal’ suture that separates the front and back of the skull...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/52814 |
| _version_ | 1811253309930995712 |
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| author | Camilla S Teng Lionel Cavin Robert E Maxson Jnr Marcelo R Sánchez-Villagra J Gage Crump |
| author_facet | Camilla S Teng Lionel Cavin Robert E Maxson Jnr Marcelo R Sánchez-Villagra J Gage Crump |
| author_sort | Camilla S Teng |
| collection | DOAJ |
| description | The vertebrate skull varies widely in shape, accommodating diverse strategies of feeding and predation. The braincase is composed of several flat bones that meet at flexible joints called sutures. Nearly all vertebrates have a prominent ‘coronal’ suture that separates the front and back of the skull. This suture can develop entirely within mesoderm-derived tissue, neural crest-derived tissue, or at the boundary of the two. Recent paleontological findings and genetic insights in non-mammalian model organisms serve to revise fundamental knowledge on the development and evolution of this suture. Growing evidence supports a decoupling of the germ layer origins of the mesenchyme that forms the calvarial bones from inductive signaling that establishes discrete bone centers. Changes in these relationships facilitate skull evolution and may create susceptibility to disease. These concepts provide a general framework for approaching issues of homology in cases where germ layer origins have shifted during evolution. |
| first_indexed | 2024-04-12T16:48:05Z |
| format | Article |
| id | doaj.art-6b668065b9e74eb6afd1d014e09d67b3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:48:05Z |
| publishDate | 2019-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-6b668065b9e74eb6afd1d014e09d67b32022-12-22T03:24:29ZengeLife Sciences Publications LtdeLife2050-084X2019-12-01810.7554/eLife.52814Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundaryCamilla S Teng0Lionel Cavin1https://orcid.org/0000-0001-9666-5864Robert E Maxson Jnr2Marcelo R Sánchez-Villagra3J Gage Crump4https://orcid.org/0000-0002-3209-0026Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States; Department of Biochemistry, Keck School of Medicine, University of Southern California, Los Angeles, United StatesDepartment of Earth Sciences, Natural History Museum of Geneva, Geneva, SwitzerlandDepartment of Biochemistry, Keck School of Medicine, University of Southern California, Los Angeles, United StatesPaleontological Institute and Museum, University of Zurich, Zurich, SwitzerlandDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United StatesThe vertebrate skull varies widely in shape, accommodating diverse strategies of feeding and predation. The braincase is composed of several flat bones that meet at flexible joints called sutures. Nearly all vertebrates have a prominent ‘coronal’ suture that separates the front and back of the skull. This suture can develop entirely within mesoderm-derived tissue, neural crest-derived tissue, or at the boundary of the two. Recent paleontological findings and genetic insights in non-mammalian model organisms serve to revise fundamental knowledge on the development and evolution of this suture. Growing evidence supports a decoupling of the germ layer origins of the mesenchyme that forms the calvarial bones from inductive signaling that establishes discrete bone centers. Changes in these relationships facilitate skull evolution and may create susceptibility to disease. These concepts provide a general framework for approaching issues of homology in cases where germ layer origins have shifted during evolution.https://elifesciences.org/articles/52814skullsutureshomology |
| spellingShingle | Camilla S Teng Lionel Cavin Robert E Maxson Jnr Marcelo R Sánchez-Villagra J Gage Crump Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary eLife skull sutures homology |
| title | Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary |
| title_full | Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary |
| title_fullStr | Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary |
| title_full_unstemmed | Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary |
| title_short | Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary |
| title_sort | resolving homology in the face of shifting germ layer origins lessons from a major skull vault boundary |
| topic | skull sutures homology |
| url | https://elifesciences.org/articles/52814 |
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