Recombinant Invasive Lactococcus lactis Carrying a DNA Vaccine Coding the Ag85A Antigen Increases INF-γ, IL-6, and TNF-α Cytokines after Intranasal Immunization

Recombinant Invasive Lactococcus lactis Carrying a DNA Vaccine Coding the Ag85A Antigen Increases INF-γ, IL-6, and TNF-α Cytokines after Intranasal Immunization

Tuberculosis (TB) remains a major threat throughout the world and in 2015 it caused the death of 1.4 million people. The Bacillus Calmette-Guérin is the only existing vaccine against this ancient disease; however, it does not provide complete protection in adults. New vaccines against TB are eminent...

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Bibliographic Details
Main Authors: Pamela Mancha-Agresti, Camila Prosperi de Castro, Janete S. C. dos Santos, Maíra A. Araujo, Vanessa B. Pereira, Jean G. LeBlanc, Sophie Y. Leclercq, Vasco Azevedo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Microbiology
Subjects:
lactic acid bacteria
Lactococcus lactis
tuberculosis
Ag85A
mucosal vaccine
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01263/full

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