What Causes the Cough in Whooping Cough?
ABSTRACT What causes the cough in whooping cough (pertussis) has been a longstanding question in the field but has been difficult to answer because of the perceived lack of convenient small animal models. Y. Hiramatsu, K. Suzuki, T. Nishida, N. Onoda, et al. (mBio 13:e01397-21, 2022, https://doi.org...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2022-06-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.00917-22 |
| _version_ | 1828804479495962624 |
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| author | Nicholas Carbonetti |
| author_facet | Nicholas Carbonetti |
| author_sort | Nicholas Carbonetti |
| collection | DOAJ |
| description | ABSTRACT What causes the cough in whooping cough (pertussis) has been a longstanding question in the field but has been difficult to answer because of the perceived lack of convenient small animal models. Y. Hiramatsu, K. Suzuki, T. Nishida, N. Onoda, et al. (mBio 13:e01397-21, 2022, https://doi.org/10.1128/mbio.03197-21) used a mouse model and cellular studies to investigate bacterial and host factors that contribute to cough production during Bordetella pertussis infection. In elegant studies, they found that the bacterial factors pertussis toxin, lipooligosaccharide, and Vag8 function cooperatively to produce cough. These factors induce production of host bradykinin, a known cough inducer that sensitizes the ion channel TRPV1 on neurons, and they investigated host signaling pathways altered by the bacterial factors that exacerbate cough responses. This is a highly significant and important finding that not only elucidates mechanisms underlying the pathophysiology of the severe cough, but also may reveal potential novel therapeutic approaches to treat individuals suffering from the debilitating effects of cough in pertussis. |
| first_indexed | 2024-12-12T07:41:13Z |
| format | Article |
| id | doaj.art-6b69a84af6044aadab7dd71e00606cb2 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-12T07:41:13Z |
| publishDate | 2022-06-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-6b69a84af6044aadab7dd71e00606cb22022-12-22T00:32:47ZengAmerican Society for MicrobiologymBio2150-75112022-06-0113310.1128/mbio.00917-22What Causes the Cough in Whooping Cough?Nicholas Carbonetti0University of Maryland School of Medicine, Baltimore, Maryland, USAABSTRACT What causes the cough in whooping cough (pertussis) has been a longstanding question in the field but has been difficult to answer because of the perceived lack of convenient small animal models. Y. Hiramatsu, K. Suzuki, T. Nishida, N. Onoda, et al. (mBio 13:e01397-21, 2022, https://doi.org/10.1128/mbio.03197-21) used a mouse model and cellular studies to investigate bacterial and host factors that contribute to cough production during Bordetella pertussis infection. In elegant studies, they found that the bacterial factors pertussis toxin, lipooligosaccharide, and Vag8 function cooperatively to produce cough. These factors induce production of host bradykinin, a known cough inducer that sensitizes the ion channel TRPV1 on neurons, and they investigated host signaling pathways altered by the bacterial factors that exacerbate cough responses. This is a highly significant and important finding that not only elucidates mechanisms underlying the pathophysiology of the severe cough, but also may reveal potential novel therapeutic approaches to treat individuals suffering from the debilitating effects of cough in pertussis.https://journals.asm.org/doi/10.1128/mbio.00917-22Bordetella pertussiscoughmouse modelpertussiswhooping cough |
| spellingShingle | Nicholas Carbonetti What Causes the Cough in Whooping Cough? mBio Bordetella pertussis cough mouse model pertussis whooping cough |
| title | What Causes the Cough in Whooping Cough? |
| title_full | What Causes the Cough in Whooping Cough? |
| title_fullStr | What Causes the Cough in Whooping Cough? |
| title_full_unstemmed | What Causes the Cough in Whooping Cough? |
| title_short | What Causes the Cough in Whooping Cough? |
| title_sort | what causes the cough in whooping cough |
| topic | Bordetella pertussis cough mouse model pertussis whooping cough |
| url | https://journals.asm.org/doi/10.1128/mbio.00917-22 |
| work_keys_str_mv | AT nicholascarbonetti whatcausesthecoughinwhoopingcough |