Dietary linoleic acid intake in relation to breast cancer: A case-control study
Background: The present study aimed to investigate the association between dietary linoleic acid (LA) intake and breast cancer in women. Methods: In this population-based case-control study, we enrolled 350 pathologically confirmed breast cancer cases and 700 controls which were matched with cases i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2023-09-01
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| Series: | Health Promotion Perspectives |
| Subjects: | |
| Online Access: | https://hpp.tbzmed.ac.ir/PDF/hpp-13-219.pdf |
| _version_ | 1797672558971060224 |
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| author | Muhammad Reza Joya Sina Naghshi Omid Sadeghi Sanaz Benisi-Kohansal Leila Azadbakht Keyhan Lotfi Alireza Ostadrahimi Helda Tutunchi Ahmad Esmaillzadeh |
| author_facet | Muhammad Reza Joya Sina Naghshi Omid Sadeghi Sanaz Benisi-Kohansal Leila Azadbakht Keyhan Lotfi Alireza Ostadrahimi Helda Tutunchi Ahmad Esmaillzadeh |
| author_sort | Muhammad Reza Joya |
| collection | DOAJ |
| description | Background: The present study aimed to investigate the association between dietary linoleic acid (LA) intake and breast cancer in women. Methods: In this population-based case-control study, we enrolled 350 pathologically confirmed breast cancer cases and 700 controls which were matched with cases in terms of age and socioeconomic status. Dietary intakes were assessed using a 106-item Willett-format semi-quantitative dish-based food frequency questionnaire (DS-FFQ). Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated. Results: A significant inverse association was found between LA intake and odds of breast cancer (OR: 0.41, 95% CI: 0.30-0.56). After adjusting for potential confounders, women in the highest tertile of dietary LA intake were 48% less likely to have breast cancer compared with those in the lowest tertile (OR: 0.52, 95% CI: 0.28-0.95). Such a significant inverse association was also seen among normal-weight women (OR: 0.29, 95% CI: 0.14-0.63), and premenopausal women (OR: 0.15, 95% CI: 0.02-0.95). Conclusion: The findings of current study provide evidence for a protective role of LA against breast cancer particularly among normal-weight and premenopausal women. Prospective studies are needed to confirm this association. |
| first_indexed | 2024-03-11T21:31:50Z |
| format | Article |
| id | doaj.art-6b6ae0ecd865414b85977cf3f1c688c9 |
| institution | Directory Open Access Journal |
| issn | 2228-6497 |
| language | English |
| last_indexed | 2024-03-11T21:31:50Z |
| publishDate | 2023-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Health Promotion Perspectives |
| spelling | doaj.art-6b6ae0ecd865414b85977cf3f1c688c92023-09-27T08:46:07ZengTabriz University of Medical SciencesHealth Promotion Perspectives2228-64972023-09-0113321922610.34172/hpp.2023.27hpp-41231Dietary linoleic acid intake in relation to breast cancer: A case-control studyMuhammad Reza Joya0Sina Naghshi1Omid Sadeghi2Sanaz Benisi-Kohansal3Leila Azadbakht4Keyhan Lotfi5Alireza Ostadrahimi6Helda Tutunchi7Ahmad Esmaillzadeh8Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, IranEndocrine Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranBackground: The present study aimed to investigate the association between dietary linoleic acid (LA) intake and breast cancer in women. Methods: In this population-based case-control study, we enrolled 350 pathologically confirmed breast cancer cases and 700 controls which were matched with cases in terms of age and socioeconomic status. Dietary intakes were assessed using a 106-item Willett-format semi-quantitative dish-based food frequency questionnaire (DS-FFQ). Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated. Results: A significant inverse association was found between LA intake and odds of breast cancer (OR: 0.41, 95% CI: 0.30-0.56). After adjusting for potential confounders, women in the highest tertile of dietary LA intake were 48% less likely to have breast cancer compared with those in the lowest tertile (OR: 0.52, 95% CI: 0.28-0.95). Such a significant inverse association was also seen among normal-weight women (OR: 0.29, 95% CI: 0.14-0.63), and premenopausal women (OR: 0.15, 95% CI: 0.02-0.95). Conclusion: The findings of current study provide evidence for a protective role of LA against breast cancer particularly among normal-weight and premenopausal women. Prospective studies are needed to confirm this association.https://hpp.tbzmed.ac.ir/PDF/hpp-13-219.pdfbreast neoplasmslinoleic aciddietcase-control studiesfatty acids |
| spellingShingle | Muhammad Reza Joya Sina Naghshi Omid Sadeghi Sanaz Benisi-Kohansal Leila Azadbakht Keyhan Lotfi Alireza Ostadrahimi Helda Tutunchi Ahmad Esmaillzadeh Dietary linoleic acid intake in relation to breast cancer: A case-control study Health Promotion Perspectives breast neoplasms linoleic acid diet case-control studies fatty acids |
| title | Dietary linoleic acid intake in relation to breast cancer: A case-control study |
| title_full | Dietary linoleic acid intake in relation to breast cancer: A case-control study |
| title_fullStr | Dietary linoleic acid intake in relation to breast cancer: A case-control study |
| title_full_unstemmed | Dietary linoleic acid intake in relation to breast cancer: A case-control study |
| title_short | Dietary linoleic acid intake in relation to breast cancer: A case-control study |
| title_sort | dietary linoleic acid intake in relation to breast cancer a case control study |
| topic | breast neoplasms linoleic acid diet case-control studies fatty acids |
| url | https://hpp.tbzmed.ac.ir/PDF/hpp-13-219.pdf |
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