Pagetoid spread of urothelial carcinoma controlled without resection
Introduction Extramammary Paget's disease is an eczematous skin condition that affects the vulva and perineum. Extramammary Paget's disease secondary to urothelial carcinoma is a rare condition that is typically treated with invasive surgical resection of the lesion. Case presentation An 8...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | IJU Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iju5.12555 |
| _version_ | 1797966547716669440 |
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| author | Shutaro Yamamoto Tatsuya Shimomura Kanako Kasai Taisuke Yamazaki Yuki Enei Yusuke Koike Toshihiro Ito Tohru Harada Nozomu Furuta Takahiro Kimura |
| author_facet | Shutaro Yamamoto Tatsuya Shimomura Kanako Kasai Taisuke Yamazaki Yuki Enei Yusuke Koike Toshihiro Ito Tohru Harada Nozomu Furuta Takahiro Kimura |
| author_sort | Shutaro Yamamoto |
| collection | DOAJ |
| description | Introduction Extramammary Paget's disease is an eczematous skin condition that affects the vulva and perineum. Extramammary Paget's disease secondary to urothelial carcinoma is a rare condition that is typically treated with invasive surgical resection of the lesion. Case presentation An 80‐year‐old woman with a 7‐year history of urothelial carcinoma presented with erythema of the labia majora. Immunostaining of skin biopsy specimens suggested extramammary Paget's disease secondary to urothelial carcinoma. The patient did not consent to resection of the lesion. Nine cycles of first‐line platinum‐based chemotherapy for metastatic urothelial carcinoma were administered. As tumor cells remained after systemic chemotherapy, pembrolizumab will be administered to the patient for treating residual extramammary Paget's disease. Conclusion Platinum‐based chemotherapy can control extramammary Paget's disease secondary to urothelial carcinoma. |
| first_indexed | 2024-04-11T02:17:10Z |
| format | Article |
| id | doaj.art-6b6b8f03f7964717a042ac393d8d16ce |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-04-11T02:17:10Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-6b6b8f03f7964717a042ac393d8d16ce2023-01-03T00:53:56ZengWileyIJU Case Reports2577-171X2023-01-0161656910.1002/iju5.12555Pagetoid spread of urothelial carcinoma controlled without resectionShutaro Yamamoto0Tatsuya Shimomura1Kanako Kasai2Taisuke Yamazaki3Yuki Enei4Yusuke Koike5Toshihiro Ito6Tohru Harada7Nozomu Furuta8Takahiro Kimura9Department of Urology The Jikei University Daisan Hospital Komae Tokyo JapanDepartment of Urology The Jikei University Daisan Hospital Komae Tokyo JapanDepartment of Urology The Jikei University Daisan Hospital Komae Tokyo JapanDepartment of Urology The Jikei University School of Medicine Minato Tokyo JapanDepartment of Urology The Jikei University Daisan Hospital Komae Tokyo JapanDepartment of Urology JR Tokyo General Hospital Shibuya Tokyo JapanDepartment of Dermatology The Jikei University Daisan Hospital Komae Tokyo JapanDepartment of Pathology The Jikei University Daisan Hospital Komae Tokyo JapanDepartment of Urology The Jikei University Daisan Hospital Komae Tokyo JapanDepartment of Urology The Jikei University School of Medicine Minato Tokyo JapanIntroduction Extramammary Paget's disease is an eczematous skin condition that affects the vulva and perineum. Extramammary Paget's disease secondary to urothelial carcinoma is a rare condition that is typically treated with invasive surgical resection of the lesion. Case presentation An 80‐year‐old woman with a 7‐year history of urothelial carcinoma presented with erythema of the labia majora. Immunostaining of skin biopsy specimens suggested extramammary Paget's disease secondary to urothelial carcinoma. The patient did not consent to resection of the lesion. Nine cycles of first‐line platinum‐based chemotherapy for metastatic urothelial carcinoma were administered. As tumor cells remained after systemic chemotherapy, pembrolizumab will be administered to the patient for treating residual extramammary Paget's disease. Conclusion Platinum‐based chemotherapy can control extramammary Paget's disease secondary to urothelial carcinoma.https://doi.org/10.1002/iju5.12555chemotherapyextramammary Paget's diseaseurinary bladder neoplasmsvulvavulvectomy |
| spellingShingle | Shutaro Yamamoto Tatsuya Shimomura Kanako Kasai Taisuke Yamazaki Yuki Enei Yusuke Koike Toshihiro Ito Tohru Harada Nozomu Furuta Takahiro Kimura Pagetoid spread of urothelial carcinoma controlled without resection IJU Case Reports chemotherapy extramammary Paget's disease urinary bladder neoplasms vulva vulvectomy |
| title | Pagetoid spread of urothelial carcinoma controlled without resection |
| title_full | Pagetoid spread of urothelial carcinoma controlled without resection |
| title_fullStr | Pagetoid spread of urothelial carcinoma controlled without resection |
| title_full_unstemmed | Pagetoid spread of urothelial carcinoma controlled without resection |
| title_short | Pagetoid spread of urothelial carcinoma controlled without resection |
| title_sort | pagetoid spread of urothelial carcinoma controlled without resection |
| topic | chemotherapy extramammary Paget's disease urinary bladder neoplasms vulva vulvectomy |
| url | https://doi.org/10.1002/iju5.12555 |
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