TET1 mutations as a predictive biomarker for immune checkpoint inhibitors in colon adenocarcinoma

TET1 mutations as a predictive biomarker for immune checkpoint inhibitors in colon adenocarcinoma

Abstract Background The ten-eleven translocation 1 (TET1), which is essential for active DNA demethylation, plays a multifaceted role in the pathogenesis of colorectal cancer. The study has demonstrated the association of TET1 mutations with a high response to immune checkpoint inhibitors (ICIs) in...

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Bibliographic Details
Main Authors: Tianzhu Qiu, Xiaoxuan Wang, Furong Du, Xiangjing Hu, Fujun Sun, Chao Song, Jie Zhao
Format: Article
Language:English
Published: BMC 2022-04-01
Series:World Journal of Surgical Oncology
Subjects:
Colon adenocarcinoma
Ten-eleven translocation 1
Immune checkpoint inhibitors
Overall survival
Predictive biomarker
Online Access:https://doi.org/10.1186/s12957-022-02581-7

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