Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition.
Half a million children die annually of severe acute malnutrition and cardiac dysfunction may contribute to the mortality. However, cardiac function remains poorly examined in cases of severe acute malnutrition.To determine malnutrition-induced echocardiographic disturbances and longitudinal changes...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4608818?pdf=render |
| _version_ | 1818151848912093184 |
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| author | Christian Fabiansen Mikkel Lykke Anne-Louise Hother Jørgen Koch Ole Bækgaard Nielsen Ingrid Hunter Jens P Goetze Henrik Friis Thomas Thymann |
| author_facet | Christian Fabiansen Mikkel Lykke Anne-Louise Hother Jørgen Koch Ole Bækgaard Nielsen Ingrid Hunter Jens P Goetze Henrik Friis Thomas Thymann |
| author_sort | Christian Fabiansen |
| collection | DOAJ |
| description | Half a million children die annually of severe acute malnutrition and cardiac dysfunction may contribute to the mortality. However, cardiac function remains poorly examined in cases of severe acute malnutrition.To determine malnutrition-induced echocardiographic disturbances and longitudinal changes in plasma pro-atrial natriuretic peptide and cardiac troponin-T in a pediatric porcine model.Five-week old piglets (Duroc-x-Danish Landrace-x-Yorkshire) were fed a nutritionally inadequate maize-flour diet to induce malnutrition (MAIZE, n = 12) or a reference diet (AGE-REF, n = 12) for 7 weeks. Outcomes were compared to a weight-matched reference group (WEIGHT-REF, n = 8). Pro-atrial natriuretic peptide and cardiac troponin-T were measured weekly. Plasma pro-atrial natriuretic peptide decreased in both MAIZE and AGE-REF during the first 3 weeks but increased markedly in MAIZE relative to AGE-REF during week 5-7 (p ≤ 0.001). There was overall no difference in plasma cardiac troponin-T between groups. However, further analysis revealed that release of cardiac troponin-T in plasma was more frequent in AGE-REF compared with MAIZE (OR: 4.8; 95%CI: 1.2-19.7; p = 0.03). However, when release occurred, cardiac troponin-T concentration was 6.9-fold higher (95%CI: 3.0-15.9; p < 0.001) in MAIZE compared to AGE-REF. At week 7, the mean body weight in MAIZE was lower than AGE-REF (8.3 vs 32.4 kg, p < 0.001), whereas heart-weight relative to body-weight was similar across the three groups. The myocardial performance index was 86% higher in MAIZE vs AGE-REF (p < 0.001) and 27% higher in MAIZE vs WEIGHT-REF (p = 0.025).Malnutrition associates with cardiac dysfunction in a pediatric porcine model by increased myocardial performance index and pro-atrial natriuretic peptide and it associates with cardiac injury by elevated cardiac troponin-T. Clinical studies are needed to see if the same applies for children suffering from malnutrition. |
| first_indexed | 2024-12-11T13:45:21Z |
| format | Article |
| id | doaj.art-6b6bb0a2156e4ba095f81d9c2c23a378 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T13:45:21Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6b6bb0a2156e4ba095f81d9c2c23a3782022-12-22T01:04:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014047210.1371/journal.pone.0140472Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition.Christian FabiansenMikkel LykkeAnne-Louise HotherJørgen KochOle Bækgaard NielsenIngrid HunterJens P GoetzeHenrik FriisThomas ThymannHalf a million children die annually of severe acute malnutrition and cardiac dysfunction may contribute to the mortality. However, cardiac function remains poorly examined in cases of severe acute malnutrition.To determine malnutrition-induced echocardiographic disturbances and longitudinal changes in plasma pro-atrial natriuretic peptide and cardiac troponin-T in a pediatric porcine model.Five-week old piglets (Duroc-x-Danish Landrace-x-Yorkshire) were fed a nutritionally inadequate maize-flour diet to induce malnutrition (MAIZE, n = 12) or a reference diet (AGE-REF, n = 12) for 7 weeks. Outcomes were compared to a weight-matched reference group (WEIGHT-REF, n = 8). Pro-atrial natriuretic peptide and cardiac troponin-T were measured weekly. Plasma pro-atrial natriuretic peptide decreased in both MAIZE and AGE-REF during the first 3 weeks but increased markedly in MAIZE relative to AGE-REF during week 5-7 (p ≤ 0.001). There was overall no difference in plasma cardiac troponin-T between groups. However, further analysis revealed that release of cardiac troponin-T in plasma was more frequent in AGE-REF compared with MAIZE (OR: 4.8; 95%CI: 1.2-19.7; p = 0.03). However, when release occurred, cardiac troponin-T concentration was 6.9-fold higher (95%CI: 3.0-15.9; p < 0.001) in MAIZE compared to AGE-REF. At week 7, the mean body weight in MAIZE was lower than AGE-REF (8.3 vs 32.4 kg, p < 0.001), whereas heart-weight relative to body-weight was similar across the three groups. The myocardial performance index was 86% higher in MAIZE vs AGE-REF (p < 0.001) and 27% higher in MAIZE vs WEIGHT-REF (p = 0.025).Malnutrition associates with cardiac dysfunction in a pediatric porcine model by increased myocardial performance index and pro-atrial natriuretic peptide and it associates with cardiac injury by elevated cardiac troponin-T. Clinical studies are needed to see if the same applies for children suffering from malnutrition.http://europepmc.org/articles/PMC4608818?pdf=render |
| spellingShingle | Christian Fabiansen Mikkel Lykke Anne-Louise Hother Jørgen Koch Ole Bækgaard Nielsen Ingrid Hunter Jens P Goetze Henrik Friis Thomas Thymann Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. PLoS ONE |
| title | Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. |
| title_full | Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. |
| title_fullStr | Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. |
| title_full_unstemmed | Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. |
| title_short | Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition. |
| title_sort | cardiac dysfunction in a porcine model of pediatric malnutrition |
| url | http://europepmc.org/articles/PMC4608818?pdf=render |
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