Effects of omecamtiv mecarbil on the contractile properties of skinned porcine left atrial and ventricular muscles

Effects of omecamtiv mecarbil on the contractile properties of skinned porcine left atrial and ventricular muscles

Omecamtiv mecarbil (OM) is a novel inotropic agent for heart failure with systolic dysfunction. OM prolongs the actomyosin attachment duration, which enhances thin filament cooperative activation and accordingly promotes the binding of neighboring myosin to actin. In the present study, we investigat...

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Bibliographic Details
Main Authors: Tomohiro Nakanishi, Kotaro Oyama, Hiroyuki Tanaka, Fuyu Kobirumaki-Shimozawa, Shuya Ishii, Takako Terui, Shin’ichi Ishiwata, Norio Fukuda
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
Ca2+ sensitivity
contractility
myocardium
sarcomere
thin filament
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.947206/full

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