The Implications of Bone Marrow Adipose Tissue on Inflammaging
Once considered an inert filler of the bone cavity, bone marrow adipose tissue (BMAT) is now regarded as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis and metabolism, and, potentially, energy conservation. While the regulation of BMAT...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.853765/full |
| _version_ | 1818313428082622464 |
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| author | Nicole Aaron Nicole Aaron Samantha Costa Samantha Costa Clifford J. Rosen Clifford J. Rosen Li Qiang Li Qiang |
| author_facet | Nicole Aaron Nicole Aaron Samantha Costa Samantha Costa Clifford J. Rosen Clifford J. Rosen Li Qiang Li Qiang |
| author_sort | Nicole Aaron |
| collection | DOAJ |
| description | Once considered an inert filler of the bone cavity, bone marrow adipose tissue (BMAT) is now regarded as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis and metabolism, and, potentially, energy conservation. While the regulation of BMAT is inadequately understood, it is recognized as a unique and dynamic fat depot that is distinct from peripheral fat. As we age, bone marrow adipocytes (BMAds) accumulate throughout the bone marrow (BM) milieu to influence the microenvironment. This process is conceivably signaled by the secretion of adipocyte-derived factors including pro-inflammatory cytokines and adipokines. Adipokines participate in the development of a chronic state of low-grade systemic inflammation (inflammaging), which trigger changes in the immune system that are characterized by declining fidelity and efficiency and cause an imbalance between pro-inflammatory and anti-inflammatory networks. In this review, we discuss the local effects of BMAT on bone homeostasis and the hematopoietic niche, age-related inflammatory changes associated with BMAT accrual, and the downstream effect on endocrine function, energy expenditure, and metabolism. Furthermore, we address therapeutic strategies to prevent BMAT accumulation and associated dysfunction during aging. In sum, BMAT is emerging as a critical player in aging and its explicit characterization still requires further research. |
| first_indexed | 2024-12-13T08:33:35Z |
| format | Article |
| id | doaj.art-6b6cd7038599457087b2010c7c83ce63 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T08:33:35Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6b6cd7038599457087b2010c7c83ce632022-12-21T23:53:42ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-03-011310.3389/fendo.2022.853765853765The Implications of Bone Marrow Adipose Tissue on InflammagingNicole Aaron0Nicole Aaron1Samantha Costa2Samantha Costa3Clifford J. Rosen4Clifford J. Rosen5Li Qiang6Li Qiang7Naomi Berrie Diabetes Center, Columbia University, New York, NY, United StatesDepartment of Pharmacology, Columbia University, New York, NY, United StatesCenter for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME, United StatesGraduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, United StatesCenter for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME, United StatesGraduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, United StatesNaomi Berrie Diabetes Center, Columbia University, New York, NY, United StatesDepartment of Pathology, Columbia University, New York, NY, United StatesOnce considered an inert filler of the bone cavity, bone marrow adipose tissue (BMAT) is now regarded as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis and metabolism, and, potentially, energy conservation. While the regulation of BMAT is inadequately understood, it is recognized as a unique and dynamic fat depot that is distinct from peripheral fat. As we age, bone marrow adipocytes (BMAds) accumulate throughout the bone marrow (BM) milieu to influence the microenvironment. This process is conceivably signaled by the secretion of adipocyte-derived factors including pro-inflammatory cytokines and adipokines. Adipokines participate in the development of a chronic state of low-grade systemic inflammation (inflammaging), which trigger changes in the immune system that are characterized by declining fidelity and efficiency and cause an imbalance between pro-inflammatory and anti-inflammatory networks. In this review, we discuss the local effects of BMAT on bone homeostasis and the hematopoietic niche, age-related inflammatory changes associated with BMAT accrual, and the downstream effect on endocrine function, energy expenditure, and metabolism. Furthermore, we address therapeutic strategies to prevent BMAT accumulation and associated dysfunction during aging. In sum, BMAT is emerging as a critical player in aging and its explicit characterization still requires further research.https://www.frontiersin.org/articles/10.3389/fendo.2022.853765/fullinflammationbone marrow adipocytesinflammagingagingbone marrow adipose tissue (BMAT) |
| spellingShingle | Nicole Aaron Nicole Aaron Samantha Costa Samantha Costa Clifford J. Rosen Clifford J. Rosen Li Qiang Li Qiang The Implications of Bone Marrow Adipose Tissue on Inflammaging Frontiers in Endocrinology inflammation bone marrow adipocytes inflammaging aging bone marrow adipose tissue (BMAT) |
| title | The Implications of Bone Marrow Adipose Tissue on Inflammaging |
| title_full | The Implications of Bone Marrow Adipose Tissue on Inflammaging |
| title_fullStr | The Implications of Bone Marrow Adipose Tissue on Inflammaging |
| title_full_unstemmed | The Implications of Bone Marrow Adipose Tissue on Inflammaging |
| title_short | The Implications of Bone Marrow Adipose Tissue on Inflammaging |
| title_sort | implications of bone marrow adipose tissue on inflammaging |
| topic | inflammation bone marrow adipocytes inflammaging aging bone marrow adipose tissue (BMAT) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.853765/full |
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