Structural imaging in the presymptomatic stage of genetically determined parkinsonism

Structural imaging in the presymptomatic stage of genetically determined parkinsonism

Several genes associated with monogenic forms of Parkinson's disease (PD) have been discovered, opening up new avenues for the investigation of presymptomatic stages of PD. Using voxel-based morphometry in 30 asymptomatic mutation carriers (MC) with mutations in four different genes for PD and...

Full description

Bibliographic Details
Main Authors:	Kathrin Reetz, Vera Tadic, Meike Kasten, Norbert Brüggemann, Alexander Schmidt, Johann Hagenah, Peter P. Pramstaller, Alfredo Ramirez, Maria I. Behrens, Hartwig R. Siebner, Christine Klein, Ferdinand Binkofski
Format:	Article
Language:	English
Published:	Elsevier 2010-09-01
Series:	Neurobiology of Disease
Subjects:	ATP13A2 Compensation Genetic parkinsonism LRRK2 Parkin PINK1
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996110001579

Similar Items

Genotype-driven therapeutic developments in Parkinson’s disease
by: Jannik Prasuhn, et al.
Published: (2021-04-01)

Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease
by: Lara Sironi, et al.
Published: (2020-01-01)

The Use of Vitamin K2 in Patients With Parkinson's Disease and Mitochondrial Dysfunction (PD-K2): A Theranostic Pilot Study in a Placebo-Controlled Parallel Group Design
by: Jannik Prasuhn, et al.
Published: (2021-01-01)

Molecular chaperones and Parkinson's disease
by: Shenglan Hu, et al.
Published: (2021-12-01)

Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration
by: Ingrid González-Casacuberta, et al.
Published: (2019-09-01)

AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson’s Disease
by: Adeline H. Basil, et al.
Published: (2017-08-01)

An omics-based strategy using coenzyme Q10 in patients with Parkinson’s disease: concept evaluation in a double-blind randomized placebo-controlled parallel group trial
by: Jannik Prasuhn, et al.
Published: (2019-08-01)

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat
by: Kristin L. Patrick, et al.
Published: (2019-05-01)

Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria
by: Marta Vranas, et al.
Published: (2022-01-01)

Effects of Telmisartan, an AT1 receptor antagonist, on mitochondria-specific genes expression in a mouse MPTP model of Parkinsonism
by: Bipul Ray, et al.
Published: (2021-08-01)

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
by: Chandana Kondapalli, et al.
Published: (2012-01-01)

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis.
by: Nicolas eDzamko, et al.
Published: (2014-06-01)

Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons
by: Jagannatham Naidu Bhupana, et al.
Published: (2020-03-01)

Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
by: Iryna Kamienieva, et al.
Published: (2021-01-01)

Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models
by: Tetsuro Abe, et al.
Published: (2021-06-01)

Role of Astrocytes in Parkinson’s Disease Associated with Genetic Mutations and Neurotoxicants
by: Sanghoon Kim, et al.
Published: (2023-02-01)

Dictyophora Polysaccharide Attenuates As-Mediated PINK1/Parkin Pathway-Induced Mitophagy in L-02 Cell through Scavenging ROS
by: Ting Hu, et al.
Published: (2022-04-01)

Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis
by: Roberto Iorio, et al.
Published: (2021-12-01)

Recent Advances in the Treatment of Genetic Forms of Parkinson’s Disease: Hype or Hope?
by: Francesco Cavallieri, et al.
Published: (2023-02-01)

Early-Onset Parkinson Disease Screening in Patients From Nigeria
by: Lukasz M. Milanowski, et al.
Published: (2021-01-01)

Effects of transport stress on the oxidative index, apoptosis and autophagy in the small intestine of caprine
by: Ruini Peng, et al.
Published: (2023-08-01)

Mitochondrial-Dependent and Independent Functions of PINK1
by: Xiusheng Chen, et al.
Published: (2022-07-01)

Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy
by: Wenqing Ji, et al.
Published: (2021-05-01)

Insights Into Parkin-Mediated Mitophagy in Alzheimer's Disease: A Systematic Review
by: Sepideh Goudarzi, et al.
Published: (2021-07-01)

History of Parkinson’s Disease-Associated Gene, <i>Parkin</i>: Research over a Quarter Century in Quest of Finding the Physiological Substrate
by: Tohru Kitada, et al.
Published: (2023-11-01)

Role and Mechanisms of Mitophagy in Liver Diseases
by: Xiaowen Ma, et al.
Published: (2020-03-01)

Mitophagy in Human Diseases
by: Laura Doblado, et al.
Published: (2021-04-01)

Electroacupuncture Exerts Chondroprotective Effect in Knee Osteoarthritis of Rabbits Through the Mitophagy Pathway
by: Xing L, et al.
Published: (2023-08-01)

PINK1/Parkin-Mediated Mitochondrial Autophagy Participates in H2O2-Induced Abnormal Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
by: Wang G, et al.
Published: (2023-03-01)

Mitophagy in Parkinson’s Disease: From Pathogenesis to Treatment
by: Jia Liu, et al.
Published: (2019-07-01)

Breviscapine remodels myocardial glucose and lipid metabolism by regulating serotonin to alleviate doxorubicin-induced cardiotoxicity
by: Meng-Jiao Li, et al.
Published: (2022-09-01)

Commentary: Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease
by: Jin-Sung Park, et al.
Published: (2017-09-01)

Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila
by: Aditya Sen, et al.
Published: (2015-06-01)

Notch1 Protects against Ischemic-Reperfusion Injury by Suppressing PTEN-Pink1-Mediated Mitochondrial Dysfunction and Mitophagy
by: Qirong Xu, et al.
Published: (2022-12-01)

Koumine inhibits IL-1β-induced chondrocyte inflammation and ameliorates extracellular matrix degradation in osteoarthritic cartilage through activation of PINK1/Parkin-mediated mitochondrial autophagy
by: Xiangyi Kong, et al.
Published: (2024-04-01)

Rare and novel variants of PRKN and PINK1 genes in Vietnamese patients with early‐onset Parkinson’s disease
by: Nguyen Dang Ton, et al.
Published: (2020-10-01)

Systematic Functional Analysis of <i>PINK1</i> and <i>PRKN</i> Coding Variants
by: Benjamin J. Broadway, et al.
Published: (2022-08-01)

Common Principles and Specific Mechanisms of Mitophagy from Yeast to Humans
by: Rajesh Kumar, et al.
Published: (2021-04-01)

Colorectal Cancer Apoptosis Induced by Dietary δ-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3
by: Nunzia D’Onofrio, et al.
Published: (2021-07-01)

Resveratrol Protects against Zearalenone-Induced Mitochondrial Defects during Porcine Oocyte Maturation via PINK1/Parkin-Mediated Mitophagy
by: Jiehuan Xu, et al.
Published: (2022-09-01)