The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma
Glioma-associated microglia/macrophages (GAM) represent an attractive therapeutic target for the development of the alternative methodology in the treatment of gliomas. This study was aimed to investigate the effect of intranasally administered TLR3 agonist Larifan on microglial cell metabolic profi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2018-11-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2018/11/Hurmach_6.pdf |
| _version_ | 1797427784585314304 |
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| author | Y. Hurmach M. Rudyk V. Svyatetska N. Senchylo O. Skachkova D. Pjanova K. Vaivode L. Skivka |
| author_facet | Y. Hurmach M. Rudyk V. Svyatetska N. Senchylo O. Skachkova D. Pjanova K. Vaivode L. Skivka |
| author_sort | Y. Hurmach |
| collection | DOAJ |
| description | Glioma-associated microglia/macrophages (GAM) represent an attractive therapeutic target for the development of the alternative methodology in the treatment of gliomas. This study was aimed to investigate the effect of intranasally administered TLR3 agonist Larifan on microglial cell metabolic profile in rats with C6 glioma. Our results demonstrate progressive generation microglial cell population with immunosuppressive and pro-inflammatory properties in C6 glioma-bearing brain. Intranasally delivered TLR3 agonist is capable to abrogate the creation of this pro-tumoral immune infiltrates, probably, through the effect on myeloid-derived suppressor cells, and can be considered as a promising agent for glioma therapy aimed the GAM re-education. |
| first_indexed | 2024-03-09T08:50:00Z |
| format | Article |
| id | doaj.art-6b6e01e112f74b39a44d548933840acb |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:50:00Z |
| publishDate | 2018-11-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-6b6e01e112f74b39a44d548933840acb2023-12-02T14:35:54ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032018-11-0190611011910.15407/ubj90.06.110The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 gliomaY. Hurmach0M. Rudyk1V. Svyatetska2N. Senchylo3O. Skachkova4D. Pjanova5K. Vaivode6L. Skivka7ESC Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, UkraineESC Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, UkraineESC Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, UkraineESC Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, UkraineResearch Laboratory of Experimental Oncology, National Cancer Institute, Kyiv, UkrainLatvian Biomedical Research and Study Centre, Riga, LatviaLatvian Biomedical Research and Study Centre, Riga, LatviaESC Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, UkraineGlioma-associated microglia/macrophages (GAM) represent an attractive therapeutic target for the development of the alternative methodology in the treatment of gliomas. This study was aimed to investigate the effect of intranasally administered TLR3 agonist Larifan on microglial cell metabolic profile in rats with C6 glioma. Our results demonstrate progressive generation microglial cell population with immunosuppressive and pro-inflammatory properties in C6 glioma-bearing brain. Intranasally delivered TLR3 agonist is capable to abrogate the creation of this pro-tumoral immune infiltrates, probably, through the effect on myeloid-derived suppressor cells, and can be considered as a promising agent for glioma therapy aimed the GAM re-education.http://ukrbiochemjournal.org/wp-content/uploads/2018/11/Hurmach_6.pdfgliomaimmunotherapymicrogliatoll-like receptor agonist |
| spellingShingle | Y. Hurmach M. Rudyk V. Svyatetska N. Senchylo O. Skachkova D. Pjanova K. Vaivode L. Skivka The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma The Ukrainian Biochemical Journal glioma immunotherapy microglia toll-like receptor agonist |
| title | The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma |
| title_full | The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma |
| title_fullStr | The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma |
| title_full_unstemmed | The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma |
| title_short | The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma |
| title_sort | effect of intranasally administered tlr3 agonist larifan on metabolic profile of microglial cells in rat with c6 glioma |
| topic | glioma immunotherapy microglia toll-like receptor agonist |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2018/11/Hurmach_6.pdf |
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