Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery
Despite considerable advances in biomaterials-based bone tissue engineering technologies, autografts remain the gold standard for rehabilitating critical-sized bone defects in the oral and maxillofacial (OMF) region. A majority of advanced synthetic bone substitutes (SBS’s) have not transcended the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/8/8/107 |
| _version_ | 1797524641367982080 |
|---|---|
| author | Lilis Iskandar Lucy DiSilvio Jonathan Acheson Sanjukta Deb |
| author_facet | Lilis Iskandar Lucy DiSilvio Jonathan Acheson Sanjukta Deb |
| author_sort | Lilis Iskandar |
| collection | DOAJ |
| description | Despite considerable advances in biomaterials-based bone tissue engineering technologies, autografts remain the gold standard for rehabilitating critical-sized bone defects in the oral and maxillofacial (OMF) region. A majority of advanced synthetic bone substitutes (SBS’s) have not transcended the pre-clinical stage due to inferior clinical performance and translational barriers, which include low scalability, high cost, regulatory restrictions, limited advanced facilities and human resources. The aim of this study is to develop clinically viable alternatives to address the challenges of bone tissue regeneration in the OMF region by developing ‘dual network composites’ (DNC’s) of calcium metaphosphate (CMP)—poly(vinyl alcohol) (PVA)/alginate with osteogenic ions: calcium, zinc and strontium. To fabricate DNC’s, single network composites of PVA/CMP with 10% (<i>w/v</i>) gelatine particles as porogen were developed using two freeze–thawing cycles and subsequently interpenetrated by guluronate-dominant sodium alginate and chelated with calcium, zinc or strontium ions. Physicochemical, compressive, water uptake, thermal, morphological and in vitro biological properties of DNC’s were characterised. The results demonstrated elastic 3D porous scaffolds resembling a ‘spongy bone’ with fluid absorbing capacity, easily sculptable to fit anatomically complex bone defects, biocompatible and osteoconductive in vitro, thus yielding potentially clinically viable for SBS alternatives in OMF surgery. |
| first_indexed | 2024-03-10T09:00:21Z |
| format | Article |
| id | doaj.art-6b6e3927119040139ae97252dbafdd84 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T09:00:21Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-6b6e3927119040139ae97252dbafdd842023-11-22T06:49:01ZengMDPI AGBioengineering2306-53542021-07-018810710.3390/bioengineering8080107Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial SurgeryLilis Iskandar0Lucy DiSilvio1Jonathan Acheson2Sanjukta Deb3Centre for Oral, Clinical & Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Floor 17, Tower Wing, Guy’s Hospital, London SE1 9RT, UKCentre for Oral, Clinical & Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Floor 17, Tower Wing, Guy’s Hospital, London SE1 9RT, UKSchool of Engineering, Ulster University, Belfast BT37 0QB, UKCentre for Oral, Clinical & Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Floor 17, Tower Wing, Guy’s Hospital, London SE1 9RT, UKDespite considerable advances in biomaterials-based bone tissue engineering technologies, autografts remain the gold standard for rehabilitating critical-sized bone defects in the oral and maxillofacial (OMF) region. A majority of advanced synthetic bone substitutes (SBS’s) have not transcended the pre-clinical stage due to inferior clinical performance and translational barriers, which include low scalability, high cost, regulatory restrictions, limited advanced facilities and human resources. The aim of this study is to develop clinically viable alternatives to address the challenges of bone tissue regeneration in the OMF region by developing ‘dual network composites’ (DNC’s) of calcium metaphosphate (CMP)—poly(vinyl alcohol) (PVA)/alginate with osteogenic ions: calcium, zinc and strontium. To fabricate DNC’s, single network composites of PVA/CMP with 10% (<i>w/v</i>) gelatine particles as porogen were developed using two freeze–thawing cycles and subsequently interpenetrated by guluronate-dominant sodium alginate and chelated with calcium, zinc or strontium ions. Physicochemical, compressive, water uptake, thermal, morphological and in vitro biological properties of DNC’s were characterised. The results demonstrated elastic 3D porous scaffolds resembling a ‘spongy bone’ with fluid absorbing capacity, easily sculptable to fit anatomically complex bone defects, biocompatible and osteoconductive in vitro, thus yielding potentially clinically viable for SBS alternatives in OMF surgery.https://www.mdpi.com/2306-5354/8/8/107bone tissue engineeringcalcium phosphatepoly(vinyl alcohol)alginateoral and maxillofacial surgery |
| spellingShingle | Lilis Iskandar Lucy DiSilvio Jonathan Acheson Sanjukta Deb Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery Bioengineering bone tissue engineering calcium phosphate poly(vinyl alcohol) alginate oral and maxillofacial surgery |
| title | Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery |
| title_full | Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery |
| title_fullStr | Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery |
| title_full_unstemmed | Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery |
| title_short | Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery |
| title_sort | dual network composites of poly vinyl alcohol calcium metaphosphate alginate with osteogenic ions for bone tissue engineering in oral and maxillofacial surgery |
| topic | bone tissue engineering calcium phosphate poly(vinyl alcohol) alginate oral and maxillofacial surgery |
| url | https://www.mdpi.com/2306-5354/8/8/107 |
| work_keys_str_mv | AT lilisiskandar dualnetworkcompositesofpolyvinylalcoholcalciummetaphosphatealginatewithosteogenicionsforbonetissueengineeringinoralandmaxillofacialsurgery AT lucydisilvio dualnetworkcompositesofpolyvinylalcoholcalciummetaphosphatealginatewithosteogenicionsforbonetissueengineeringinoralandmaxillofacialsurgery AT jonathanacheson dualnetworkcompositesofpolyvinylalcoholcalciummetaphosphatealginatewithosteogenicionsforbonetissueengineeringinoralandmaxillofacialsurgery AT sanjuktadeb dualnetworkcompositesofpolyvinylalcoholcalciummetaphosphatealginatewithosteogenicionsforbonetissueengineeringinoralandmaxillofacialsurgery |