Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series
Abstract Background Hypogonadism in older men is often considered as late onset hypogonadism. However, this clinical condition results from primary testicular failure which could be of genetic origin with Klinefelter syndrome being the most common chromosomal abnormality associated with it. Case pre...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-023-01359-6 |
| _version_ | 1797822807421222912 |
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| author | Tarik Elhadd Ahmad Majzoub Charlotte Wilson Laura McCreight Muna S. Mohamed Fiona C. Green Andrew J. Collier |
| author_facet | Tarik Elhadd Ahmad Majzoub Charlotte Wilson Laura McCreight Muna S. Mohamed Fiona C. Green Andrew J. Collier |
| author_sort | Tarik Elhadd |
| collection | DOAJ |
| description | Abstract Background Hypogonadism in older men is often considered as late onset hypogonadism. However, this clinical condition results from primary testicular failure which could be of genetic origin with Klinefelter syndrome being the most common chromosomal abnormality associated with it. Case presentation We report a heterogeneous group of cases who were diagnosed with hypergonadotropic hypogonadism in their adulthood and were found to have rare chromosomal aberrations. All were elderly men (in their 70 s and 80 s) for whom the diagnosis was made during the evaluation of incidental symptoms suggestive of endocrinopathy. The first had hyponatremia; the other two had gynaecomastia and features of hypogonadism noted during admission for various acute medical problems. With respect to their genetic results; the first had a male karyotype with balanced reciprocal translocation between the long arm of chromosome 4 and the short arm of chromosome 7. The second case had a male karotype with one normal X chromosome and an isochrome for the short arm of the Y chromosome. The third case was an XX male with unbalanced translocation between the X & Y chromosomes with retention of the SRY locus. Conclusion Hypergonadotrophic hypogonadism in the elderly, may be due to chromosomal aberrations, resulting in heterogeneous and diverse clinical phenotypes. Vigilance must be exercised when seeing cases with subtle clinical findings. This report suggests that in selected cases of adult hypergonadotropic hypogonadism, chromosomal analysis may be indicated. |
| first_indexed | 2024-03-13T10:14:36Z |
| format | Article |
| id | doaj.art-6b70206e095b4b68a35067825e456c0b |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-13T10:14:36Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-6b70206e095b4b68a35067825e456c0b2023-05-21T11:18:32ZengBMCBMC Endocrine Disorders1472-68232023-05-012311610.1186/s12902-023-01359-6Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case seriesTarik Elhadd0Ahmad Majzoub1Charlotte Wilson2Laura McCreight3Muna S. Mohamed4Fiona C. Green5Andrew J. Collier6Department of Medicine, Qatar Metabolic Institute, Hamad Medical CorporationDepartment of Urology, Hamad Medical CorporationDepartment of Medicine, Ayr HospitalDepartment of Medicine, Ninewells Hospital & Medical SchoolDepartment of Medicine, Dumfries and Galloway Royal InfirmaryDepartment of Medicine, Dumfries and Galloway Royal InfirmaryDepartment of Medicine, Ayr HospitalAbstract Background Hypogonadism in older men is often considered as late onset hypogonadism. However, this clinical condition results from primary testicular failure which could be of genetic origin with Klinefelter syndrome being the most common chromosomal abnormality associated with it. Case presentation We report a heterogeneous group of cases who were diagnosed with hypergonadotropic hypogonadism in their adulthood and were found to have rare chromosomal aberrations. All were elderly men (in their 70 s and 80 s) for whom the diagnosis was made during the evaluation of incidental symptoms suggestive of endocrinopathy. The first had hyponatremia; the other two had gynaecomastia and features of hypogonadism noted during admission for various acute medical problems. With respect to their genetic results; the first had a male karyotype with balanced reciprocal translocation between the long arm of chromosome 4 and the short arm of chromosome 7. The second case had a male karotype with one normal X chromosome and an isochrome for the short arm of the Y chromosome. The third case was an XX male with unbalanced translocation between the X & Y chromosomes with retention of the SRY locus. Conclusion Hypergonadotrophic hypogonadism in the elderly, may be due to chromosomal aberrations, resulting in heterogeneous and diverse clinical phenotypes. Vigilance must be exercised when seeing cases with subtle clinical findings. This report suggests that in selected cases of adult hypergonadotropic hypogonadism, chromosomal analysis may be indicated.https://doi.org/10.1186/s12902-023-01359-6Male hypogonadismChromosomal abnormalitiesElderlyHypergonadotropic hypogonadism |
| spellingShingle | Tarik Elhadd Ahmad Majzoub Charlotte Wilson Laura McCreight Muna S. Mohamed Fiona C. Green Andrew J. Collier Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series BMC Endocrine Disorders Male hypogonadism Chromosomal abnormalities Elderly Hypergonadotropic hypogonadism |
| title | Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series |
| title_full | Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series |
| title_fullStr | Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series |
| title_full_unstemmed | Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series |
| title_short | Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series |
| title_sort | hypergonadotropic hypogonadism and chromosomal aberrations clinical heterogeneity and implications on the health of elderly men case series |
| topic | Male hypogonadism Chromosomal abnormalities Elderly Hypergonadotropic hypogonadism |
| url | https://doi.org/10.1186/s12902-023-01359-6 |
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