In vivo TCR signaling in CD4+ T cells imprints a cell-intrinsic, transient low motility pattern independent of chemokine receptor expression levels or microtubular network, integrin and protein kinase C activity
Intravital imaging has revealed that T cells change their migratory behavior during physiological activation inside lymphoid tissue. Yet, it remains less well investigated how the intrinsic migratory capacity of activated T cells is regulated by chemokine receptor levels or other regulatory elements...
Main Authors: | Markus eAckerknecht, Mark A Hauser, Daniel F Legler, Jens Volker Stein |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-06-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00297/full |
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