Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients
Early prediction of kidney graft function may assist clinical management, and for this, reliable non-invasive biomarkers are needed. We evaluated endotrophin (ETP), a novel non-invasive biomarker of collagen type VI formation, as a prognostic marker in kidney transplant recipients. ETP levels were m...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/5/792 |
| _version_ | 1797600850011488256 |
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| author | Nadja Sparding Federica Genovese Daniel Guldager Kring Rasmussen Morten A. Karsdal Nicoline V. Krogstrup Marie Bodilsen Nielsen Mads Hornum Subagini Nagarajah Henrik Birn The CONTEXT Study Group Bente Jespersen Martin Tepel Rikke Nørregaard |
| author_facet | Nadja Sparding Federica Genovese Daniel Guldager Kring Rasmussen Morten A. Karsdal Nicoline V. Krogstrup Marie Bodilsen Nielsen Mads Hornum Subagini Nagarajah Henrik Birn The CONTEXT Study Group Bente Jespersen Martin Tepel Rikke Nørregaard |
| author_sort | Nadja Sparding |
| collection | DOAJ |
| description | Early prediction of kidney graft function may assist clinical management, and for this, reliable non-invasive biomarkers are needed. We evaluated endotrophin (ETP), a novel non-invasive biomarker of collagen type VI formation, as a prognostic marker in kidney transplant recipients. ETP levels were measured with the PRO-C6 ELISA in the plasma (P-ETP) of 218 and urine (U-ETP/Cr) of 172 kidney transplant recipients, one (D1) and five (D5) days, as well as three (M3) and twelve (M12) months, after transplantation. P-ETP and U-ETP/Cr at D1 (P-ETP AUC = 0.86, <i>p</i> < 0.0001; U-ETP/Cr AUC = 0.70, <i>p</i> = 0.0002) were independent markers of delayed graft function (DGF) and P-ETP at D1 had an odds ratio of 6.3 (<i>p</i> < 0.0001) for DGF when adjusted for plasma creatinine. The results for P-ETP at D1 were confirmed in a validation cohort of 146 transplant recipients (AUC = 0.92, <i>p</i> < 0.0001). U-ETP/Cr at M3 was negatively associated with kidney graft function at M12 (<i>p</i> = 0.007). This study suggests that ETP at D1 can identify patients at risk of delayed graft function and that U-ETP/Cr at M3 can predict the future status of the allograft. Thus, measuring collagen type VI formation could aid in predicting graft function in kidney transplant recipients. |
| first_indexed | 2024-03-11T03:54:46Z |
| format | Article |
| id | doaj.art-6b7179723dfd45a48c824c320306cac4 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T03:54:46Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6b7179723dfd45a48c824c320306cac42023-11-18T00:39:16ZengMDPI AGBiomolecules2218-273X2023-05-0113579210.3390/biom13050792Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant RecipientsNadja Sparding0Federica Genovese1Daniel Guldager Kring Rasmussen2Morten A. Karsdal3Nicoline V. Krogstrup4Marie Bodilsen Nielsen5Mads Hornum6Subagini Nagarajah7Henrik Birn8The CONTEXT Study GroupBente Jespersen9Martin Tepel10Rikke Nørregaard11Nordic Bioscience, 2730 Herlev, DenmarkNordic Bioscience, 2730 Herlev, DenmarkNordic Bioscience, 2730 Herlev, DenmarkNordic Bioscience, 2730 Herlev, DenmarkDepartment of Renal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Renal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Nephrology, Rigshospitalet and Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, DenmarkDepartment of Nephrology, Odense University Hospital, 5000 Odense, DenmarkDepartment of Renal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Renal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Nephrology, Odense University Hospital, 5000 Odense, DenmarkDepartment of Clinical Medicine, Aarhus University, 8000 Aarhus, DenmarkEarly prediction of kidney graft function may assist clinical management, and for this, reliable non-invasive biomarkers are needed. We evaluated endotrophin (ETP), a novel non-invasive biomarker of collagen type VI formation, as a prognostic marker in kidney transplant recipients. ETP levels were measured with the PRO-C6 ELISA in the plasma (P-ETP) of 218 and urine (U-ETP/Cr) of 172 kidney transplant recipients, one (D1) and five (D5) days, as well as three (M3) and twelve (M12) months, after transplantation. P-ETP and U-ETP/Cr at D1 (P-ETP AUC = 0.86, <i>p</i> < 0.0001; U-ETP/Cr AUC = 0.70, <i>p</i> = 0.0002) were independent markers of delayed graft function (DGF) and P-ETP at D1 had an odds ratio of 6.3 (<i>p</i> < 0.0001) for DGF when adjusted for plasma creatinine. The results for P-ETP at D1 were confirmed in a validation cohort of 146 transplant recipients (AUC = 0.92, <i>p</i> < 0.0001). U-ETP/Cr at M3 was negatively associated with kidney graft function at M12 (<i>p</i> = 0.007). This study suggests that ETP at D1 can identify patients at risk of delayed graft function and that U-ETP/Cr at M3 can predict the future status of the allograft. Thus, measuring collagen type VI formation could aid in predicting graft function in kidney transplant recipients.https://www.mdpi.com/2218-273X/13/5/792biomarkersfibrosisdelayed graft functionkidney transplantationkidney failure |
| spellingShingle | Nadja Sparding Federica Genovese Daniel Guldager Kring Rasmussen Morten A. Karsdal Nicoline V. Krogstrup Marie Bodilsen Nielsen Mads Hornum Subagini Nagarajah Henrik Birn The CONTEXT Study Group Bente Jespersen Martin Tepel Rikke Nørregaard Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients Biomolecules biomarkers fibrosis delayed graft function kidney transplantation kidney failure |
| title | Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients |
| title_full | Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients |
| title_fullStr | Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients |
| title_full_unstemmed | Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients |
| title_short | Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients |
| title_sort | endotrophin levels are associated with allograft outcomes in kidney transplant recipients |
| topic | biomarkers fibrosis delayed graft function kidney transplantation kidney failure |
| url | https://www.mdpi.com/2218-273X/13/5/792 |
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