Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors
Adjuvant treatment with Imatinib is the standard of care for high-risk resected GISTs. Imatinib is known to have an impact on bone mineral density in patients affected by chronic myeloid leukemia, however this effect has never been investigated in GISTs.We retrospectively evaluated, on CT scans, the...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of Bone Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137422000124 |
| _version_ | 1828795938518335488 |
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| author | Claudia Angela Maria Fulgenzi Andrea Napolitano Eliodoro Faiella Laura Messina Gennaro Castiello Flavia Paternostro Marianna Silletta Francesco Pantano Giuseppe Tonini Daniele Santini Bruno Vincenzi |
| author_facet | Claudia Angela Maria Fulgenzi Andrea Napolitano Eliodoro Faiella Laura Messina Gennaro Castiello Flavia Paternostro Marianna Silletta Francesco Pantano Giuseppe Tonini Daniele Santini Bruno Vincenzi |
| author_sort | Claudia Angela Maria Fulgenzi |
| collection | DOAJ |
| description | Adjuvant treatment with Imatinib is the standard of care for high-risk resected GISTs. Imatinib is known to have an impact on bone mineral density in patients affected by chronic myeloid leukemia, however this effect has never been investigated in GISTs.We retrospectively evaluated, on CT scans, the effect of adjuvant Imatinib (400 mg/die) on bone mineral density and muscle composition in 14 patients with surgically resected GISTs and in a control group of 8 patients who did not received any treatment. The effect of bone and muscle composition on Imatinib-tolerance was assessed as well.Overall patients receiving Imatinib experienced an increase in bone mineral density during treatment (p = 0.021); with higher increase in patients with basal values < 120 mg/cm3 (p = 0.002). No changes were observed in the control group (p = 0.918).Skeletal muscle index and lean body mass did not change over time during Imatinib therapy; however, patients with lower lean body mass and lower body mass index experienced more grade 3 treatment related toxicities (p = 0.024 and p = 0.014 respectively). We also found a non-significant trend between basal BMD and grade 3 toxicities (p = 0.060) |
| first_indexed | 2024-12-12T04:12:50Z |
| format | Article |
| id | doaj.art-6b71d272acba46989af605eba6f809c1 |
| institution | Directory Open Access Journal |
| issn | 2212-1374 |
| language | English |
| last_indexed | 2024-12-12T04:12:50Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj.art-6b71d272acba46989af605eba6f809c12022-12-22T00:38:34ZengElsevierJournal of Bone Oncology2212-13742022-06-0134100422Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumorsClaudia Angela Maria Fulgenzi0Andrea Napolitano1Eliodoro Faiella2Laura Messina3Gennaro Castiello4Flavia Paternostro5Marianna Silletta6Francesco Pantano7Giuseppe Tonini8Daniele Santini9Bruno Vincenzi10Division of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, ItalyDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, Italy; Corresponding author at: Via Alvaro del Portillo 200, Rome, ItalyUnit of Diagnostic Imaging, Policlinico Universitario Campus Bio-Medico, Rome, ItalyUnit of Diagnostic Imaging, Policlinico Universitario Campus Bio-Medico, Rome, ItalyUnit of Diagnostic Imaging, Policlinico Universitario Campus Bio-Medico, Rome, ItalyDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, ItalyDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, ItalyDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, ItalyDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, ItalyDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, ItalyDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, ItalyAdjuvant treatment with Imatinib is the standard of care for high-risk resected GISTs. Imatinib is known to have an impact on bone mineral density in patients affected by chronic myeloid leukemia, however this effect has never been investigated in GISTs.We retrospectively evaluated, on CT scans, the effect of adjuvant Imatinib (400 mg/die) on bone mineral density and muscle composition in 14 patients with surgically resected GISTs and in a control group of 8 patients who did not received any treatment. The effect of bone and muscle composition on Imatinib-tolerance was assessed as well.Overall patients receiving Imatinib experienced an increase in bone mineral density during treatment (p = 0.021); with higher increase in patients with basal values < 120 mg/cm3 (p = 0.002). No changes were observed in the control group (p = 0.918).Skeletal muscle index and lean body mass did not change over time during Imatinib therapy; however, patients with lower lean body mass and lower body mass index experienced more grade 3 treatment related toxicities (p = 0.024 and p = 0.014 respectively). We also found a non-significant trend between basal BMD and grade 3 toxicities (p = 0.060)http://www.sciencedirect.com/science/article/pii/S2212137422000124GISTsImatinibBone mineral densityMuscle compositionImatinib-related toxicities |
| spellingShingle | Claudia Angela Maria Fulgenzi Andrea Napolitano Eliodoro Faiella Laura Messina Gennaro Castiello Flavia Paternostro Marianna Silletta Francesco Pantano Giuseppe Tonini Daniele Santini Bruno Vincenzi Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors Journal of Bone Oncology GISTs Imatinib Bone mineral density Muscle composition Imatinib-related toxicities |
| title | Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors |
| title_full | Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors |
| title_fullStr | Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors |
| title_full_unstemmed | Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors |
| title_short | Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors |
| title_sort | impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors |
| topic | GISTs Imatinib Bone mineral density Muscle composition Imatinib-related toxicities |
| url | http://www.sciencedirect.com/science/article/pii/S2212137422000124 |
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