AS03-adjuvanted, very-low-dose influenza vaccines induce distinctive immune responses compared to unadjuvanted high-dose vaccines in BALB/c mice

AS03-adjuvanted, very-low-dose influenza vaccines induce distinctive immune responses compared to unadjuvanted high-dose vaccines in BALB/c mice

During the 2009-2010 influenza pandemic, an adjuvanted, dose-sparing vaccine was recommended for most Canadians. We hypothesize that differences exist in the responses to AS03-adjuvanted, low antigen (Ag) dose versus unadjuvanted, full-dose vaccines. We investigated the relationship between Ag dose...

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Bibliographic Details
Main Authors: Karen K Yam, Jyotsana eGupta, Kaitlin eWinter, Elizabeth eAllen, Angela eBrewer, Édith eBeaulieu, Corey P Mallett, David S Burt, Brian J Ward
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Immunology
Subjects:
Vaccine
influenza
adjuvant
AS03
dose-sparing
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00207/full

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