One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum
The use of freshwater invertebrates for biomonitoring has been increasing for several decades, but little is known about relations between external exposure concentration of metals and their biodistribution among different tissues. One and multi-compartments toxicokinetic (TK) models are powerful to...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021002506 |
| _version_ | 1818607687900856320 |
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| author | Ophélia Gestin Thomas Lacoue-Labarthe Marina Coquery Nicolas Delorme Laura Garnero Lysiane Dherret Théo Ciccia Olivier Geffard Christelle Lopes |
| author_facet | Ophélia Gestin Thomas Lacoue-Labarthe Marina Coquery Nicolas Delorme Laura Garnero Lysiane Dherret Théo Ciccia Olivier Geffard Christelle Lopes |
| author_sort | Ophélia Gestin |
| collection | DOAJ |
| description | The use of freshwater invertebrates for biomonitoring has been increasing for several decades, but little is known about relations between external exposure concentration of metals and their biodistribution among different tissues. One and multi-compartments toxicokinetic (TK) models are powerful tools to formalize and predict how a contaminant is bioaccumulated. The aim of this study is to develop modeling approaches to improve knowledge on dynamic of accumulation and fate of Cd and Hg in gammarid’s organs. Gammarids were exposed to dissolved metals (11.1 ± 1.2 µg.L−1 of Cd or 0.27 ± 0.13 µg.L−1 of Hg) before a depuration phase. At each sampling days, their organs (caeca, cephalon, intestine and remaining tissues) were separated by dissection before analyses. Results allowed us to determine that i) G. fossarum takes up Cd as efficiently as the mussel M. galloprovincialis, but eliminates it more rapidly, ii) organs which accumulate and depurate the most, in terms of concentrations, are caeca and intestine for both metals; iii) the one-compartment TK models is the most relevant for Hg, while the multi-compartments TK model allows a better fit to Cd data, demonstrating dynamic transfer of Cd among organs. |
| first_indexed | 2024-12-16T14:30:43Z |
| format | Article |
| id | doaj.art-6b7291bfabb84a04a6f7f5206899816e |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-16T14:30:43Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-6b7291bfabb84a04a6f7f5206899816e2022-12-21T22:28:15ZengElsevierEnvironment International0160-41202021-11-01156106625One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarumOphélia Gestin0Thomas Lacoue-Labarthe1Marina Coquery2Nicolas Delorme3Laura Garnero4Lysiane Dherret5Théo Ciccia6Olivier Geffard7Christelle Lopes8Univ Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, 69622 Villeurbanne, France; Littoral Environnement et Sociétés (LIENSs), UMR 7266 CNRS – Université de la Rochelle, 2 rue Olympe de Gouges, 17000 La Rochelle, France; INRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceLittoral Environnement et Sociétés (LIENSs), UMR 7266 CNRS – Université de la Rochelle, 2 rue Olympe de Gouges, 17000 La Rochelle, FranceINRAE, RiverLy, Aquatic Chemistry Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceINRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceINRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceINRAE, RiverLy, Aquatic Chemistry Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceINRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceINRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceINRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, France; Corresponding author at: Laboratoire de Biométrie et Biologie Évolutive UM R5558, Université Lyon 1 (CNRS), 69622 Villeurbanne, France.The use of freshwater invertebrates for biomonitoring has been increasing for several decades, but little is known about relations between external exposure concentration of metals and their biodistribution among different tissues. One and multi-compartments toxicokinetic (TK) models are powerful tools to formalize and predict how a contaminant is bioaccumulated. The aim of this study is to develop modeling approaches to improve knowledge on dynamic of accumulation and fate of Cd and Hg in gammarid’s organs. Gammarids were exposed to dissolved metals (11.1 ± 1.2 µg.L−1 of Cd or 0.27 ± 0.13 µg.L−1 of Hg) before a depuration phase. At each sampling days, their organs (caeca, cephalon, intestine and remaining tissues) were separated by dissection before analyses. Results allowed us to determine that i) G. fossarum takes up Cd as efficiently as the mussel M. galloprovincialis, but eliminates it more rapidly, ii) organs which accumulate and depurate the most, in terms of concentrations, are caeca and intestine for both metals; iii) the one-compartment TK models is the most relevant for Hg, while the multi-compartments TK model allows a better fit to Cd data, demonstrating dynamic transfer of Cd among organs.http://www.sciencedirect.com/science/article/pii/S0160412021002506OrganotropismAmphipodsCadmiumMercuryToxico-kinetic modelBayesian Inference |
| spellingShingle | Ophélia Gestin Thomas Lacoue-Labarthe Marina Coquery Nicolas Delorme Laura Garnero Lysiane Dherret Théo Ciccia Olivier Geffard Christelle Lopes One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum Environment International Organotropism Amphipods Cadmium Mercury Toxico-kinetic model Bayesian Inference |
| title | One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum |
| title_full | One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum |
| title_fullStr | One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum |
| title_full_unstemmed | One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum |
| title_short | One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum |
| title_sort | one and multi compartments toxico kinetic modeling to understand metals organotropism and fate in gammarus fossarum |
| topic | Organotropism Amphipods Cadmium Mercury Toxico-kinetic model Bayesian Inference |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021002506 |
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