Synthesis and Applications of Selected Fluorine-Containing Fluorophores
The synthesis of fluorine-containing small molecules has had numerous benefits of improving the quality and efficiency of many applications of these compounds. For example, fluorine adds promising functionalities in various areas of imaging (MRI, PET, and NIR); gives cell-targeting properties; and h...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/4/1160 |
| _version_ | 1797395644712747008 |
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| author | Stefanie Casa Maged Henary |
| author_facet | Stefanie Casa Maged Henary |
| author_sort | Stefanie Casa |
| collection | DOAJ |
| description | The synthesis of fluorine-containing small molecules has had numerous benefits of improving the quality and efficiency of many applications of these compounds. For example, fluorine adds promising functionalities in various areas of imaging (MRI, PET, and NIR); gives cell-targeting properties; and has demonstrated improvements in cell permeability, solubility, and other pharmacologic properties. For these and other numerous reasons, fluorination of molecules has grown in popularity in various fields of chemistry. Many reports show the effects observed from increasing the number of fluorine atoms on a fluorophore scaffold. This report will cover the most significant applications and improvements that fluorine has contributed to in various dye scaffolds such as BODIPY, rhodamine, phthalocyanine, and cyanine in the recent decade. |
| first_indexed | 2024-03-09T00:38:28Z |
| format | Article |
| id | doaj.art-6b733f17fcd84a62b421c17be928cb26 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T00:38:28Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6b733f17fcd84a62b421c17be928cb262023-12-11T17:58:31ZengMDPI AGMolecules1420-30492021-02-01264116010.3390/molecules26041160Synthesis and Applications of Selected Fluorine-Containing FluorophoresStefanie Casa0Maged Henary1Department of Chemistry, Petit Science Center, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA 30303, USADepartment of Chemistry, Petit Science Center, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA 30303, USAThe synthesis of fluorine-containing small molecules has had numerous benefits of improving the quality and efficiency of many applications of these compounds. For example, fluorine adds promising functionalities in various areas of imaging (MRI, PET, and NIR); gives cell-targeting properties; and has demonstrated improvements in cell permeability, solubility, and other pharmacologic properties. For these and other numerous reasons, fluorination of molecules has grown in popularity in various fields of chemistry. Many reports show the effects observed from increasing the number of fluorine atoms on a fluorophore scaffold. This report will cover the most significant applications and improvements that fluorine has contributed to in various dye scaffolds such as BODIPY, rhodamine, phthalocyanine, and cyanine in the recent decade.https://www.mdpi.com/1420-3049/26/4/1160fluorine chemistryoptical fluorophoresPET imagingPDTcontrast agents |
| spellingShingle | Stefanie Casa Maged Henary Synthesis and Applications of Selected Fluorine-Containing Fluorophores Molecules fluorine chemistry optical fluorophores PET imaging PDT contrast agents |
| title | Synthesis and Applications of Selected Fluorine-Containing Fluorophores |
| title_full | Synthesis and Applications of Selected Fluorine-Containing Fluorophores |
| title_fullStr | Synthesis and Applications of Selected Fluorine-Containing Fluorophores |
| title_full_unstemmed | Synthesis and Applications of Selected Fluorine-Containing Fluorophores |
| title_short | Synthesis and Applications of Selected Fluorine-Containing Fluorophores |
| title_sort | synthesis and applications of selected fluorine containing fluorophores |
| topic | fluorine chemistry optical fluorophores PET imaging PDT contrast agents |
| url | https://www.mdpi.com/1420-3049/26/4/1160 |
| work_keys_str_mv | AT stefaniecasa synthesisandapplicationsofselectedfluorinecontainingfluorophores AT magedhenary synthesisandapplicationsofselectedfluorinecontainingfluorophores |