Histone lactylation regulates cancer progression by reshaping the tumor microenvironment
As a major product of glycolysis and a vital signaling molecule, many studies have reported the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly discovered post-translational modification induced by lactate. On the one hand, lactylation introduced a new er...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1284344/full |
| _version_ | 1797647958856957952 |
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| author | Junxing Qu Peizhi Li Zhiheng Sun |
| author_facet | Junxing Qu Peizhi Li Zhiheng Sun |
| author_sort | Junxing Qu |
| collection | DOAJ |
| description | As a major product of glycolysis and a vital signaling molecule, many studies have reported the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly discovered post-translational modification induced by lactate. On the one hand, lactylation introduced a new era of lactate metabolism in the tumor microenvironment (TME), and on the other hand, it provided a key breakthrough point for elucidation of the interaction between tumor metabolic reprogramming and epigenetic modification. Studies have shown that the lactylation of tumor cells, tumor stem cells and tumor-infiltrating immune cells in TME can participate in the development of cancer through downstream transcriptional regulation, and is a potential and promising tumor treatment target. This review summarized the discovery and effects of lactylation, as well as recent research on histone lactylation regulating cancer progression through reshaping TME. We also focused on new strategies to enhance anti-tumor effects via targeting lactylation. Finally, we discussed the limitations of existing studies and proposed new perspectives for future research in order to further explore lactylation targets. It may provide a new way and direction to improve tumor prognosis. |
| first_indexed | 2024-03-11T15:25:10Z |
| format | Article |
| id | doaj.art-6b73694b6eb34c9284a29007ed18ec3c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T15:25:10Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6b73694b6eb34c9284a29007ed18ec3c2023-10-27T22:19:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12843441284344Histone lactylation regulates cancer progression by reshaping the tumor microenvironmentJunxing Qu0Peizhi Li1Zhiheng Sun2Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang, ChinaThe First People’s Hospital of Xinxiang City, The Fifth Clinical College of Xinxiang Medical University, Xinxiang, ChinaCollege of Life Science, Institute of Biomedical Science, Henan Normal University, Xinxiang, Henan, ChinaAs a major product of glycolysis and a vital signaling molecule, many studies have reported the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly discovered post-translational modification induced by lactate. On the one hand, lactylation introduced a new era of lactate metabolism in the tumor microenvironment (TME), and on the other hand, it provided a key breakthrough point for elucidation of the interaction between tumor metabolic reprogramming and epigenetic modification. Studies have shown that the lactylation of tumor cells, tumor stem cells and tumor-infiltrating immune cells in TME can participate in the development of cancer through downstream transcriptional regulation, and is a potential and promising tumor treatment target. This review summarized the discovery and effects of lactylation, as well as recent research on histone lactylation regulating cancer progression through reshaping TME. We also focused on new strategies to enhance anti-tumor effects via targeting lactylation. Finally, we discussed the limitations of existing studies and proposed new perspectives for future research in order to further explore lactylation targets. It may provide a new way and direction to improve tumor prognosis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1284344/fulllactylationtumor microenvironmentimmune cellscancer therapyepigenetic modification |
| spellingShingle | Junxing Qu Peizhi Li Zhiheng Sun Histone lactylation regulates cancer progression by reshaping the tumor microenvironment Frontiers in Immunology lactylation tumor microenvironment immune cells cancer therapy epigenetic modification |
| title | Histone lactylation regulates cancer progression by reshaping the tumor microenvironment |
| title_full | Histone lactylation regulates cancer progression by reshaping the tumor microenvironment |
| title_fullStr | Histone lactylation regulates cancer progression by reshaping the tumor microenvironment |
| title_full_unstemmed | Histone lactylation regulates cancer progression by reshaping the tumor microenvironment |
| title_short | Histone lactylation regulates cancer progression by reshaping the tumor microenvironment |
| title_sort | histone lactylation regulates cancer progression by reshaping the tumor microenvironment |
| topic | lactylation tumor microenvironment immune cells cancer therapy epigenetic modification |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1284344/full |
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