The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences
Introduction: The yellow fever vaccine is a live attenuated virus vaccine that is considered one of the most efficient vaccines produced to date. The original 17D strain generated the substrains 17D-204 and 17DD, which are used for the current production of vaccines against yellow fever. The 17D-204...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2018.1406800 |
| _version_ | 1797680418794766336 |
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| author | Clarissa de Castro Ferreira Ana Carolina Campi-Azevedo Vanessa Peruhype-Magalhāes Christiane Costa-Pereira Cleandro Pires de Albuquerque Luciana Feitosa Muniz Talita Yokoy de Souza Ana Cristina Vanderley Oliveira Olindo Assis Martins-Filho Licia Maria Henrique da Mota |
| author_facet | Clarissa de Castro Ferreira Ana Carolina Campi-Azevedo Vanessa Peruhype-Magalhāes Christiane Costa-Pereira Cleandro Pires de Albuquerque Luciana Feitosa Muniz Talita Yokoy de Souza Ana Cristina Vanderley Oliveira Olindo Assis Martins-Filho Licia Maria Henrique da Mota |
| author_sort | Clarissa de Castro Ferreira |
| collection | DOAJ |
| description | Introduction: The yellow fever vaccine is a live attenuated virus vaccine that is considered one of the most efficient vaccines produced to date. The original 17D strain generated the substrains 17D-204 and 17DD, which are used for the current production of vaccines against yellow fever. The 17D-204 and 17DD substrains present subtle differences in their nucleotide compositions, which can potentially lead to variations in immunogenicity and reactogenicity. We will address the main changes in the immune responses induced by the 17D-204 and 17DD yellow fever vaccines and report similarities and differences between these vaccines in cellular and humoral immunity . This is a relevant issue in view of the re-emergence of yellow fever in Uganda in 2016 and in Brazil in the beginning of 2017. Areas covered: This article will be divided into 8 sections that will analyze the innate immune response, adaptive immune response, humoral response, production of cytokines, immunity in children, immunity in the elderly, gene expression and adverse reactions. Expert commentary: The 17D-204 and 17DD yellow fever vaccines present similar immunogenicity, with strong activation of the cellular and humoral immune responses. Additionally, both vaccines have similar adverse effects, which are mostly mild and thus are considered safe. |
| first_indexed | 2024-03-11T23:29:45Z |
| format | Article |
| id | doaj.art-6b776b36671a4334a80487b33f8d262d |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:45Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-6b776b36671a4334a80487b33f8d262d2023-09-20T10:18:03ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952018-01-01171799010.1080/14760584.2018.14068001406800The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differencesClarissa de Castro Ferreira0Ana Carolina Campi-Azevedo1Vanessa Peruhype-Magalhāes2Christiane Costa-Pereira3Cleandro Pires de Albuquerque4Luciana Feitosa Muniz5Talita Yokoy de Souza6Ana Cristina Vanderley Oliveira7Olindo Assis Martins-Filho8Licia Maria Henrique da Mota9University Hospital of Brasilia, University of BrasiliaFIOCRUZFIOCRUZFIOCRUZUniversity Hospital of Brasilia, University of BrasiliaUniversity Hospital of Brasilia, University of BrasiliaUniversity Hospital of Brasilia, University of BrasiliaUniversity Hospital of Brasilia, University of BrasiliaFIOCRUZUniversity Hospital of Brasilia, University of BrasiliaIntroduction: The yellow fever vaccine is a live attenuated virus vaccine that is considered one of the most efficient vaccines produced to date. The original 17D strain generated the substrains 17D-204 and 17DD, which are used for the current production of vaccines against yellow fever. The 17D-204 and 17DD substrains present subtle differences in their nucleotide compositions, which can potentially lead to variations in immunogenicity and reactogenicity. We will address the main changes in the immune responses induced by the 17D-204 and 17DD yellow fever vaccines and report similarities and differences between these vaccines in cellular and humoral immunity . This is a relevant issue in view of the re-emergence of yellow fever in Uganda in 2016 and in Brazil in the beginning of 2017. Areas covered: This article will be divided into 8 sections that will analyze the innate immune response, adaptive immune response, humoral response, production of cytokines, immunity in children, immunity in the elderly, gene expression and adverse reactions. Expert commentary: The 17D-204 and 17DD yellow fever vaccines present similar immunogenicity, with strong activation of the cellular and humoral immune responses. Additionally, both vaccines have similar adverse effects, which are mostly mild and thus are considered safe.http://dx.doi.org/10.1080/14760584.2018.1406800adaptive immune responseadverse reactionsinnate immune responseyellow feveryellow fever vaccinecytokines |
| spellingShingle | Clarissa de Castro Ferreira Ana Carolina Campi-Azevedo Vanessa Peruhype-Magalhāes Christiane Costa-Pereira Cleandro Pires de Albuquerque Luciana Feitosa Muniz Talita Yokoy de Souza Ana Cristina Vanderley Oliveira Olindo Assis Martins-Filho Licia Maria Henrique da Mota The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences Expert Review of Vaccines adaptive immune response adverse reactions innate immune response yellow fever yellow fever vaccine cytokines |
| title | The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences |
| title_full | The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences |
| title_fullStr | The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences |
| title_full_unstemmed | The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences |
| title_short | The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences |
| title_sort | 17d 204 and 17dd yellow fever vaccines an overview of major similarities and subtle differences |
| topic | adaptive immune response adverse reactions innate immune response yellow fever yellow fever vaccine cytokines |
| url | http://dx.doi.org/10.1080/14760584.2018.1406800 |
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