A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer
The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/352 |
| _version_ | 1797716392514945024 |
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| author | Li Liu Lu Yan Ning Liao Wan-Qin Wu Jun-Ling Shi |
| author_facet | Li Liu Lu Yan Ning Liao Wan-Qin Wu Jun-Ling Shi |
| author_sort | Li Liu |
| collection | DOAJ |
| description | The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (ULK1) is a serine/threonine kinase that participates in the initiation of autophagy. Many studies have indicated that compounds that directly or indirectly target ULK1 could be used for tumor therapy. However, reports of the therapeutic effects of these compounds have come to conflicting conclusions. In this work, we reviewed recent studies related to the effects of ULK1 on the regulation of autophagy and the development of drug resistance in cancers, with the aim of clarifying the mechanistic underpinnings of this therapeutic target. |
| first_indexed | 2024-03-12T08:20:46Z |
| format | Article |
| id | doaj.art-6b79c06351b549f29388a6a562bd5163 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T08:20:46Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6b79c06351b549f29388a6a562bd51632023-09-02T18:29:04ZengMDPI AGCancers2072-66942020-02-0112235210.3390/cancers12020352cancers12020352A Review of ULK1-Mediated Autophagy in Drug Resistance of CancerLi Liu0Lu Yan1Ning Liao2Wan-Qin Wu3Jun-Ling Shi4Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi’an 710072, ChinaKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi’an 710072, ChinaKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi’an 710072, ChinaKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi’an 710072, ChinaKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi’an 710072, ChinaThe difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (ULK1) is a serine/threonine kinase that participates in the initiation of autophagy. Many studies have indicated that compounds that directly or indirectly target ULK1 could be used for tumor therapy. However, reports of the therapeutic effects of these compounds have come to conflicting conclusions. In this work, we reviewed recent studies related to the effects of ULK1 on the regulation of autophagy and the development of drug resistance in cancers, with the aim of clarifying the mechanistic underpinnings of this therapeutic target.https://www.mdpi.com/2072-6694/12/2/352ulk1autophagycancerdrug resistance |
| spellingShingle | Li Liu Lu Yan Ning Liao Wan-Qin Wu Jun-Ling Shi A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer Cancers ulk1 autophagy cancer drug resistance |
| title | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
| title_full | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
| title_fullStr | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
| title_full_unstemmed | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
| title_short | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
| title_sort | review of ulk1 mediated autophagy in drug resistance of cancer |
| topic | ulk1 autophagy cancer drug resistance |
| url | https://www.mdpi.com/2072-6694/12/2/352 |
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