Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma
We describe a case of papillated Bowen disease (PBD), associated with a clear cell atypical fibroxanthoma (CCAFXA). The epidermal lesion showed a bowenoid papillomatous growth pattern with histologic features suggestive of infection by human papilloma virus (HPV). In the dermis a neoplasm made up by...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2010-05-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/314232 |
| _version_ | 1811209488460414976 |
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| author | Dimas Suárez-Vilela Francisco Izquierdo-García Francisco Domínguez-Iglesias Jose Ramón Méndez-Álvarez |
| author_facet | Dimas Suárez-Vilela Francisco Izquierdo-García Francisco Domínguez-Iglesias Jose Ramón Méndez-Álvarez |
| author_sort | Dimas Suárez-Vilela |
| collection | DOAJ |
| description | We describe a case of papillated Bowen disease (PBD), associated with a clear cell atypical fibroxanthoma (CCAFXA). The epidermal lesion showed a bowenoid papillomatous growth pattern with histologic features suggestive of infection by human papilloma virus (HPV). In the dermis a neoplasm made up by spindled or polygonal cells with wide clear cytoplasm and moderate nuclear pleomorphism was found. Immunohistochemical characteristics of these two lesions were clearly different. The atypical cells of the intraepidermal proliferation were positive for AE1-AE3 anticytokeratin antibody, EMA, p16, p53 and p63. The dermal tumor was positive for vimentin, CD10, CD68, CD99, alpha-1-antitrypsin and c-kit. Histological features and immunohistochemical profile of the dermal tumor corresponded to a CCAFXA, a very uncommon neoplasm of which only 10 cases have been reported. In situ hybridization for numerous types of HPVs was negative in both lesions. |
| first_indexed | 2024-04-12T04:38:58Z |
| format | Article |
| id | doaj.art-6b7c1bf51b6145fb9f7695c294529437 |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-04-12T04:38:58Z |
| publishDate | 2010-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-6b7c1bf51b6145fb9f7695c2945294372022-12-22T03:47:42ZengKarger PublishersCase Reports in Dermatology1662-65672010-05-0122697510.1159/000314232314232Combined Papillated Bowen Disease and Clear Cell Atypical FibroxanthomaDimas Suárez-VilelaFrancisco Izquierdo-GarcíaFrancisco Domínguez-IglesiasJose Ramón Méndez-ÁlvarezWe describe a case of papillated Bowen disease (PBD), associated with a clear cell atypical fibroxanthoma (CCAFXA). The epidermal lesion showed a bowenoid papillomatous growth pattern with histologic features suggestive of infection by human papilloma virus (HPV). In the dermis a neoplasm made up by spindled or polygonal cells with wide clear cytoplasm and moderate nuclear pleomorphism was found. Immunohistochemical characteristics of these two lesions were clearly different. The atypical cells of the intraepidermal proliferation were positive for AE1-AE3 anticytokeratin antibody, EMA, p16, p53 and p63. The dermal tumor was positive for vimentin, CD10, CD68, CD99, alpha-1-antitrypsin and c-kit. Histological features and immunohistochemical profile of the dermal tumor corresponded to a CCAFXA, a very uncommon neoplasm of which only 10 cases have been reported. In situ hybridization for numerous types of HPVs was negative in both lesions.http://www.karger.com/Article/FullText/314232Clear cell atypical fibroxanthomap16Papillated Bowen diseaseBowen diseaseAtypical fibroxanthomaImmunohistochemistry |
| spellingShingle | Dimas Suárez-Vilela Francisco Izquierdo-García Francisco Domínguez-Iglesias Jose Ramón Méndez-Álvarez Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma Case Reports in Dermatology Clear cell atypical fibroxanthoma p16 Papillated Bowen disease Bowen disease Atypical fibroxanthoma Immunohistochemistry |
| title | Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma |
| title_full | Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma |
| title_fullStr | Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma |
| title_full_unstemmed | Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma |
| title_short | Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma |
| title_sort | combined papillated bowen disease and clear cell atypical fibroxanthoma |
| topic | Clear cell atypical fibroxanthoma p16 Papillated Bowen disease Bowen disease Atypical fibroxanthoma Immunohistochemistry |
| url | http://www.karger.com/Article/FullText/314232 |
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