Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
Neuroblastoma, the most common extracranial solid tumor of childhood, has widely variable outcomes dependent on the specific biology of the tumor. In this review, current biologic principles that are used to stratify risk and guide treatment algorithms are discussed. The role for surgical resection...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Children |
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| Online Access: | http://www.mdpi.com/2227-9067/6/1/12 |
| _version_ | 1818407138082422784 |
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| author | Kyle J. Van Arendonk Dai H. Chung |
| author_facet | Kyle J. Van Arendonk Dai H. Chung |
| author_sort | Kyle J. Van Arendonk |
| collection | DOAJ |
| description | Neuroblastoma, the most common extracranial solid tumor of childhood, has widely variable outcomes dependent on the specific biology of the tumor. In this review, current biologic principles that are used to stratify risk and guide treatment algorithms are discussed. The role for surgical resection in neuroblastoma is also reviewed, including the indications and timing of surgery within the greater treatment plan. |
| first_indexed | 2024-12-14T09:23:04Z |
| format | Article |
| id | doaj.art-6b7d191392d14f858104597e9916bcd2 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-12-14T09:23:04Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-6b7d191392d14f858104597e9916bcd22022-12-21T23:08:16ZengMDPI AGChildren2227-90672019-01-01611210.3390/children6010012children6010012Neuroblastoma: Tumor Biology and Its Implications for Staging and TreatmentKyle J. Van Arendonk0Dai H. Chung1Department of Surgery, Children’s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Surgery, Children’s Medical Center Dallas, UT Southwestern Medical Center, Dallas, TX 75235, USANeuroblastoma, the most common extracranial solid tumor of childhood, has widely variable outcomes dependent on the specific biology of the tumor. In this review, current biologic principles that are used to stratify risk and guide treatment algorithms are discussed. The role for surgical resection in neuroblastoma is also reviewed, including the indications and timing of surgery within the greater treatment plan.http://www.mdpi.com/2227-9067/6/1/12neuroblastomaoncologypediatricpathologysurgery |
| spellingShingle | Kyle J. Van Arendonk Dai H. Chung Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment Children neuroblastoma oncology pediatric pathology surgery |
| title | Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment |
| title_full | Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment |
| title_fullStr | Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment |
| title_full_unstemmed | Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment |
| title_short | Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment |
| title_sort | neuroblastoma tumor biology and its implications for staging and treatment |
| topic | neuroblastoma oncology pediatric pathology surgery |
| url | http://www.mdpi.com/2227-9067/6/1/12 |
| work_keys_str_mv | AT kylejvanarendonk neuroblastomatumorbiologyanditsimplicationsforstagingandtreatment AT daihchung neuroblastomatumorbiologyanditsimplicationsforstagingandtreatment |