MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines

MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines

In cancer therapy, radioresistance or chemoresistance cells are major problems. We established clinically relevant radioresistant (CRR) cells that can survive over 30 days after 2 Gy/day X-ray exposures. These cells also show resistance to anticancer agents and hydrogen peroxide (H<sub>2</s...

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Bibliographic Details
Main Authors: Kazuo Tomita, Taisuke Nagasawa, Yoshikazu Kuwahara, Seiji Torii, Kento Igarashi, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Akihiro Kurimasa, Tomoaki Sato
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
microRNA
reactive oxygen species (ROS)
clinically relevant radioresistant (CRR) cells
ferroptosis
Fe<sup>2+</sup>
<i>ALOX12</i>
Online Access:https://www.mdpi.com/1422-0067/22/15/8300

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