Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal
Summary: Fear learning, and its extinction, are fundamental learning processes that allow for a response adaptation to aversive events and threats in the environment. Thus, it is critical to understand the neural mechanism that underpins fear learning and its relapse following extinction. The neural...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222013086 |
| _version_ | 1811261435987099648 |
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| author | Cong Wang Peter G. Stratton Pankaj Sah Roger Marek |
| author_facet | Cong Wang Peter G. Stratton Pankaj Sah Roger Marek |
| author_sort | Cong Wang |
| collection | DOAJ |
| description | Summary: Fear learning, and its extinction, are fundamental learning processes that allow for a response adaptation to aversive events and threats in the environment. Thus, it is critical to understand the neural mechanism that underpins fear learning and its relapse following extinction. The neural dynamics within the subregions of the medial prefrontal cortex, including the prelimbic cortex (PL) and the infralimbic (IL) cortex, and functional connectivity between them during fear extinction and its relapse, are not well understood. Using in-vivo electrophysiological recordings in awake behaving rats, we identified increased theta activity in the PL during fear learning and in the IL following extinction. Importantly, the PL-IL theta coupling is significantly enhanced throughout fear learning and extinction, but not in fear relapse. Together, our results provide evidence for the importance of synchronized PL-IL activity to regulate context-dependent retrieval of a fear extinction memory. |
| first_indexed | 2024-04-12T19:04:16Z |
| format | Article |
| id | doaj.art-6b80fa490c2146b899fde145b79e9ec5 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-12T19:04:16Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-6b80fa490c2146b899fde145b79e9ec52022-12-22T03:20:04ZengElsevieriScience2589-00422022-10-012510105036Theta coupling within the medial prefrontal cortex regulates fear extinction and renewalCong Wang0Peter G. Stratton1Pankaj Sah2Roger Marek3Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China; Queensland Brain Institute, The University of Queensland, Brisbane, Australia; Australian Research Council Centre of Excellence for Integrative Brain Function, Melbourne, Australia; Corresponding authorQueensland Brain Institute, The University of Queensland, Brisbane, AustraliaQueensland Brain Institute, The University of Queensland, Brisbane, Australia; Australian Research Council Centre of Excellence for Integrative Brain Function, Melbourne, Australia; Joint Center for Neuroscience and Neural Engineering, and Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong Province, P. R. China, 518055; Corresponding authorQueensland Brain Institute, The University of Queensland, Brisbane, Australia; Australian Research Council Centre of Excellence for Integrative Brain Function, Melbourne, Australia; Corresponding authorSummary: Fear learning, and its extinction, are fundamental learning processes that allow for a response adaptation to aversive events and threats in the environment. Thus, it is critical to understand the neural mechanism that underpins fear learning and its relapse following extinction. The neural dynamics within the subregions of the medial prefrontal cortex, including the prelimbic cortex (PL) and the infralimbic (IL) cortex, and functional connectivity between them during fear extinction and its relapse, are not well understood. Using in-vivo electrophysiological recordings in awake behaving rats, we identified increased theta activity in the PL during fear learning and in the IL following extinction. Importantly, the PL-IL theta coupling is significantly enhanced throughout fear learning and extinction, but not in fear relapse. Together, our results provide evidence for the importance of synchronized PL-IL activity to regulate context-dependent retrieval of a fear extinction memory.http://www.sciencedirect.com/science/article/pii/S2589004222013086Behavioral neurosciencebiological sciencesneurosciencesensory neuroscience |
| spellingShingle | Cong Wang Peter G. Stratton Pankaj Sah Roger Marek Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal iScience Behavioral neuroscience biological sciences neuroscience sensory neuroscience |
| title | Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal |
| title_full | Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal |
| title_fullStr | Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal |
| title_full_unstemmed | Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal |
| title_short | Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal |
| title_sort | theta coupling within the medial prefrontal cortex regulates fear extinction and renewal |
| topic | Behavioral neuroscience biological sciences neuroscience sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222013086 |
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