Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease
Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD–MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel therapeutic approaches, mouse models are essential. CKD...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5325 |
| _version_ | 1797611309380927488 |
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| author | Ariane Zaloszyc Julie Bernardor Justine Bacchetta Gilles Laverny Claus Peter Schmitt |
| author_facet | Ariane Zaloszyc Julie Bernardor Justine Bacchetta Gilles Laverny Claus Peter Schmitt |
| author_sort | Ariane Zaloszyc |
| collection | DOAJ |
| description | Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD–MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel therapeutic approaches, mouse models are essential. CKD can be induced by surgical reduction of a functional kidney mass, by nephrotoxic compounds and by genetic engineering specifically interfering with kidney development. These models develop a large range of bone diseases, recapitulating different types of human CKD–MBD and associated sequelae, including vascular calcifications. Bones are usually studied by quantitative histomorphometry, immunohistochemistry and micro-CT, but alternative strategies have emerged, such as longitudinal in vivo osteoblast activity quantification by tracer scintigraphy. The results gained from the CKD–MBD mouse models are consistent with clinical observations and have provided significant knowledge on specific pathomechanisms, bone properties and potential novel therapeutic strategies. This review discusses available mouse models to study bone disease in CKD. |
| first_indexed | 2024-03-11T06:27:04Z |
| format | Article |
| id | doaj.art-6b812348f30e45188fb907d6ce1499cf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:27:04Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6b812348f30e45188fb907d6ce1499cf2023-11-17T11:32:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246532510.3390/ijms24065325Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney DiseaseAriane Zaloszyc0Julie Bernardor1Justine Bacchetta2Gilles Laverny3Claus Peter Schmitt4Service de Pédiatrie 1, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, FranceService de Néphrologie Pédiatrique, CHU de Nice, Hôpital Archet, 06202 Nice, FranceINSERM UMR S1033 Research Unit, 69008 Lyon, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, FranceCenter for Pediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, GermanyPatients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD–MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel therapeutic approaches, mouse models are essential. CKD can be induced by surgical reduction of a functional kidney mass, by nephrotoxic compounds and by genetic engineering specifically interfering with kidney development. These models develop a large range of bone diseases, recapitulating different types of human CKD–MBD and associated sequelae, including vascular calcifications. Bones are usually studied by quantitative histomorphometry, immunohistochemistry and micro-CT, but alternative strategies have emerged, such as longitudinal in vivo osteoblast activity quantification by tracer scintigraphy. The results gained from the CKD–MBD mouse models are consistent with clinical observations and have provided significant knowledge on specific pathomechanisms, bone properties and potential novel therapeutic strategies. This review discusses available mouse models to study bone disease in CKD.https://www.mdpi.com/1422-0067/24/6/5325CKDmiceCKD–MBDrenal osteodystrophy |
| spellingShingle | Ariane Zaloszyc Julie Bernardor Justine Bacchetta Gilles Laverny Claus Peter Schmitt Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease International Journal of Molecular Sciences CKD mice CKD–MBD renal osteodystrophy |
| title | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
| title_full | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
| title_fullStr | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
| title_full_unstemmed | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
| title_short | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
| title_sort | mouse models of mineral bone disorders associated with chronic kidney disease |
| topic | CKD mice CKD–MBD renal osteodystrophy |
| url | https://www.mdpi.com/1422-0067/24/6/5325 |
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