Autophagy in Metabolic Age-Related Human Diseases
Autophagy is a highly conserved homeostatic cellular mechanism that mediates the degradation of damaged organelles, protein aggregates, and invading pathogens through a lysosome-dependent pathway. Over the last few years, specific functions of autophagy have been discovered in many tissues and organ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-09-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/7/10/149 |
| _version_ | 1797709342497046528 |
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| author | Manon Moulis Cecile Vindis |
| author_facet | Manon Moulis Cecile Vindis |
| author_sort | Manon Moulis |
| collection | DOAJ |
| description | Autophagy is a highly conserved homeostatic cellular mechanism that mediates the degradation of damaged organelles, protein aggregates, and invading pathogens through a lysosome-dependent pathway. Over the last few years, specific functions of autophagy have been discovered in many tissues and organs; however, abnormal upregulation or downregulation of autophagy has been depicted as an attribute of a variety of pathologic conditions. In this review, we will describe the current knowledge on the role of autophagy, from its regulation to its physiological influence, in metabolic age-related disorders. Finally, we propose to discuss the therapeutic potential of pharmacological and nutritional modulators of autophagy to treat metabolic diseases. |
| first_indexed | 2024-03-12T06:35:04Z |
| format | Article |
| id | doaj.art-6b8321eeea8f4f26bcc4ec4303f8df23 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:35:04Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6b8321eeea8f4f26bcc4ec4303f8df232023-09-03T01:21:23ZengMDPI AGCells2073-44092018-09-0171014910.3390/cells7100149cells7100149Autophagy in Metabolic Age-Related Human DiseasesManon Moulis0Cecile Vindis1INSERM, UMR-1048, Institute of Cardiovascular and Metabolic Diseases and University Paul Sabatier; F-31342 Toulouse, FranceINSERM, UMR-1048, Institute of Cardiovascular and Metabolic Diseases and University Paul Sabatier; F-31342 Toulouse, FranceAutophagy is a highly conserved homeostatic cellular mechanism that mediates the degradation of damaged organelles, protein aggregates, and invading pathogens through a lysosome-dependent pathway. Over the last few years, specific functions of autophagy have been discovered in many tissues and organs; however, abnormal upregulation or downregulation of autophagy has been depicted as an attribute of a variety of pathologic conditions. In this review, we will describe the current knowledge on the role of autophagy, from its regulation to its physiological influence, in metabolic age-related disorders. Finally, we propose to discuss the therapeutic potential of pharmacological and nutritional modulators of autophagy to treat metabolic diseases.http://www.mdpi.com/2073-4409/7/10/149autophagymetabolismdiabetesobesityliver diseasesatherosclerosispharmacological modulators |
| spellingShingle | Manon Moulis Cecile Vindis Autophagy in Metabolic Age-Related Human Diseases Cells autophagy metabolism diabetes obesity liver diseases atherosclerosis pharmacological modulators |
| title | Autophagy in Metabolic Age-Related Human Diseases |
| title_full | Autophagy in Metabolic Age-Related Human Diseases |
| title_fullStr | Autophagy in Metabolic Age-Related Human Diseases |
| title_full_unstemmed | Autophagy in Metabolic Age-Related Human Diseases |
| title_short | Autophagy in Metabolic Age-Related Human Diseases |
| title_sort | autophagy in metabolic age related human diseases |
| topic | autophagy metabolism diabetes obesity liver diseases atherosclerosis pharmacological modulators |
| url | http://www.mdpi.com/2073-4409/7/10/149 |
| work_keys_str_mv | AT manonmoulis autophagyinmetabolicagerelatedhumandiseases AT cecilevindis autophagyinmetabolicagerelatedhumandiseases |