The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

Gene duplication is a driver of the evolution of new functions. The duplication of genes encoding homomeric proteins leads to the formation of homomers and heteromers of paralogs, creating new complexes after a single duplication event. The loss of these heteromers may be required for the two paralo...

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Bibliographic Details
Main Authors: Axelle Marchant, Angel F Cisneros, Alexandre K Dubé, Isabelle Gagnon-Arsenault, Diana Ascencio, Honey Jain, Simon Aubé, Chris Eberlein, Daniel Evans-Yamamoto, Nozomu Yachie, Christian R Landry
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
gene duplication
protein interaction networks
pleiotropy
regulatory evolution
epistasis
Online Access:https://elifesciences.org/articles/46754

Internet

https://elifesciences.org/articles/46754

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